Literature DB >> 11160028

Mice lacking interleukin-2 (IL-2)/IL-15 receptor beta chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar choleraesuis but mice lacking IL-2 are resistant.

H Nishimura1, M Tagaya, H Tsunobuchi, H Suzuki, I Nakashima, Y Yoshikai.   

Abstract

Interleukin-2 (IL-2)/IL-15 receptor beta (IL-15R beta)(-/-) mice were susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis, whereas IL-2(-/-) mice were resistant. A natural killer cell response was not evident for both types of deficient mice. A Th1 response was detected in IL-2(-/-) but not in IL-2/IL-15R beta(-/-) mice infected with Salmonella, suggesting that IL-2/IL-15R beta signaling is important for the generation of protective Th1 cells.

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Year:  2001        PMID： 11160028      PMCID： PMC98012          DOI： 10.1128/IAI.69.2.1226-1229.2001

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  11 in total

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Journal:  Immunity       Date:  1998-05       Impact factor: 31.745

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Journal:  J Exp Med       Date:  1997-03-03       Impact factor: 14.307

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Authors:  H Suzuki; G S Duncan; H Takimoto; T W Mak
Journal:  J Exp Med       Date:  1997-02-03       Impact factor: 14.307

9.  Differential roles of interleukin 15 mRNA isoforms generated by alternative splicing in immune responses in vivo.

Authors:  H Nishimura; T Yajima; Y Naiki; H Tsunobuchi; M Umemura; K Itano; T Matsuguchi; M Suzuki; P S Ohashi; Y Yoshikai
Journal:  J Exp Med       Date:  2000-01-03       Impact factor: 14.307

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Authors:  M Emoto; H Danbara; Y Yoshikai
Journal:  J Exp Med       Date:  1992-08-01       Impact factor: 14.307
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  1 in total

1.  Interleukin-15 and NK1.1+ cells provide innate protection against acute Salmonella enterica serovar Typhimurium infection in the gut and in systemic tissues.

Authors:  Ali A Ashkar; Sarah Reid; Elena F Verdu; Kun Zhang; Brian K Coombes
Journal:  Infect Immun       Date:  2008-11-17       Impact factor: 3.441
  1 in total

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