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Literature DB >> 11160026

Restoration of Mga function to a Streptococcus pyogenes strain (M Type 50) that is virulent in mice.

B Limbago¹, K S McIver, V Penumalli, B Weinrick, J R Scott.

Abstract

The Mga protein in B514Sm, a Streptococcus pyogenes strain isolated as a mouse pathogen, contains amino acid substitutions at conserved sites that render the protein defective. Replacement of mga50 with the functional homolog mga4.1 restored full expression of Mga-regulated proteins. Restoration of Mga function did not affect fibrinogen binding, nor did it affect virulence in several mouse models of group A streptococcus infection.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2001 PMID： 11160026 PMCID： PMC98010 DOI： 10.1128/IAI.69.2.1215-1220.2001

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

58 in total

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Journal: J Bacteriol Date: 1985-10 Impact factor: 3.490

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Journal: Infect Immun Date: 1997-04 Impact factor: 3.441

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Journal: J Infect Dis Date: 1999-04 Impact factor: 5.226

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Journal: Proc Natl Acad Sci U S A Date: 1992-09-15 Impact factor: 11.205

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Journal: Infect Immun Date: 1993-08 Impact factor: 3.441

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Journal: J Clin Invest Date: 1994-09 Impact factor: 14.808

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Journal: Infect Immun Date: 1992-01 Impact factor: 3.441

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Journal: Mol Microbiol Date: 1998-10 Impact factor: 3.501

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Journal: J Exp Med Date: 1985-12-01 Impact factor: 14.307

4 in total

1. Identification of residues responsible for the defective virulence gene regulator Mga produced by a natural mutant of Streptococcus pyogenes.

Authors: Cheryl M Vahling; Kevin S McIver
Journal: J Bacteriol Date: 2005-09 Impact factor: 3.490