Literature DB >> 11160016

Macrophage-derived cell lines do not express proinflammatory cytokines after exposure to Bacillus anthracis lethal toxin.

J L Erwin1, L M DaSilva, S Bavari, S F Little, A M Friedlander, T C Chanh.   

Abstract

We present evidence that Bacillus anthracis lethal toxin (LT) suppresses rather than induces proinflammatory cytokine production in macrophages. Suppression is observed with extremely low levels of LT and involves inhibition of transcription of cytokine messenger RNA. Thus, LT may contribute to anthrax pathogenesis by suppressing the inflammatory response.

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Year:  2001        PMID： 11160016      PMCID： PMC98000          DOI： 10.1128/IAI.69.2.1175-1177.2001

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  7 in total

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