Literature DB >> 11158773

Therapeutic potential of human neutrophil peptide 1 against experimental tuberculosis.

S Sharma1, I Verma, G K Khuller.   

Abstract

The therapeutic efficacy of human neutrophil peptide 1 (HNP-1) against experimental tuberculosis in mice on the basis of numbers of CFU has been examined. Mice infected with 1.5 x 10(4) CFU of Mycobacterium tuberculosis H(37)Rv and treated with different doses of HNP-1 injected subcutaneously exhibited significant clearance of bacilli from lungs, livers, and spleens. There were time- and dose-dependent decreases in the bacillary load in lungs, livers, and spleens of the HNP-1-treated animals compared to that in controls (untreated animals). These observations strongly suggest the therapeutic activity of HNP-1 against tuberculosis.

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Year:  2001        PMID： 11158773      PMCID： PMC90345          DOI： 10.1128/AAC.45.2.639-640.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

Review 1.  Antibiotic peptides from higher eukaryotes: biology and applications.

Authors:  T Ganz; R I Lehrer
Journal:  Mol Med Today       Date:  1999-07

2.  Antibacterial activity of human neutrophil peptide-1 against Mycobacterium tuberculosis H37Rv: in vitro and ex vivo study.

Authors:  S Sharma; I Verma; G K Khuller
Journal:  Eur Respir J       Date:  2000-07       Impact factor: 16.671

Review 3.  Antibiotic proteins of polymorphonuclear leukocytes.

Authors:  O Levy
Journal:  Eur J Haematol       Date:  1996-05       Impact factor: 2.997

4.  Monocyte-chemotactic activity of defensins from human neutrophils.

Authors:  M C Territo; T Ganz; M E Selsted; R Lehrer
Journal:  J Clin Invest       Date:  1989-12       Impact factor: 14.808

5.  Effect of defensins on interleukin-8 synthesis in airway epithelial cells.

Authors:  S Van Wetering; S P Mannesse-Lazeroms; M A Van Sterkenburg; M R Daha; J H Dijkman; P S Hiemstra
Journal:  Am J Physiol       Date:  1997-05

6.  Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils.

Authors:  O Chertov; D F Michiel; L Xu; J M Wang; K Tani; W J Murphy; D L Longo; D D Taub; J J Oppenheim
Journal:  J Biol Chem       Date:  1996-02-09       Impact factor: 5.157

7.  Biochemical interaction of human neutrophil peptide-1 with Mycobacterium tuberculosis H37Ra.

Authors:  S Sharma; I Verma; G K Khuller
Journal:  Arch Microbiol       Date:  1999-04       Impact factor: 2.552

8.  In vitro activity of the antimicrobial peptides human and rabbit defensins and porcine leukocyte protegrin against Mycobacterium tuberculosis.

Authors:  Y Miyakawa; P Ratnakar; A G Rao; M L Costello; O Mathieu-Costello; R I Lehrer; A Catanzaro
Journal:  Infect Immun       Date:  1996-03       Impact factor: 3.441

9.  Antibacterial activity of human neutrophil defensins in experimental infections in mice is accompanied by increased leukocyte accumulation.

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Journal:  J Clin Invest       Date:  1998-10-15       Impact factor: 14.808

10.  Activity of defensins from human neutrophilic granulocytes against Mycobacterium avium-Mycobacterium intracellulare.

Authors:  K Ogata; B A Linzer; R I Zuberi; T Ganz; R I Lehrer; A Catanzaro
Journal:  Infect Immun       Date:  1992-11       Impact factor: 3.441
  10 in total
  17 in total

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3.  Induction of β-defensins by l-isoleucine as novel immunotherapy in experimental murine tuberculosis.

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4.  Contribution of the Mycobacterium tuberculosis MmpL protein family to virulence and drug resistance.

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Journal:  Infect Immun       Date:  2005-06       Impact factor: 3.441

5.  Expression of cathelicidin LL-37 during Mycobacterium tuberculosis infection in human alveolar macrophages, monocytes, neutrophils, and epithelial cells.

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6.  Expression and secretion of cathelicidin LL-37 in human epithelial cells after infection by Mycobacterium bovis Bacillus Calmette-Guérin.

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Journal:  Clin Vaccine Immunol       Date:  2008-06-25

7.  Polymorphisms in α-Defensin-Encoding DEFA1A3 Associate with Urinary Tract Infection Risk in Children with Vesicoureteral Reflux.

Authors:  Andrew L Schwaderer; Huanyu Wang; SungHwan Kim; Jennifer M Kline; Dong Liang; Pat D Brophy; Kirk M McHugh; George C Tseng; Vijay Saxena; Evan Barr-Beare; Keith R Pierce; Nader Shaikh; J Robert Manak; Daniel M Cohen; Brian Becknell; John D Spencer; Peter B Baker; Chack-Yung Yu; David S Hains
Journal:  J Am Soc Nephrol       Date:  2016-03-03       Impact factor: 10.121

8.  Respiratory syncytial virus-induced dysregulation of expression of a mucosal beta-defensin augments colonization of the upper airway by non-typeable Haemophilus influenzae.

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Journal:  Cell Microbiol       Date:  2009-06-02       Impact factor: 3.715

Review 9.  Neutrophils in Tuberculosis: Cell Biology, Cellular Networking and Multitasking in Host Defense.

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Journal:  Int J Mol Sci       Date:  2021-04-30       Impact factor: 5.923

10.  Azurophil granule proteins constitute the major mycobactericidal proteins in human neutrophils and enhance the killing of mycobacteria in macrophages.

Authors:  Prajna Jena; Soumitra Mohanty; Tirthankar Mohanty; Stephanie Kallert; Matthias Morgelin; Thomas Lindstrøm; Niels Borregaard; Steffen Stenger; Avinash Sonawane; Ole E Sørensen
Journal:  PLoS One       Date:  2012-12-14       Impact factor: 3.240
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