Literature DB >> 1115871

Decreased incidence of indomethacin-induced gastric ulceration in rats by bile duct diversion.

F S Abtahi, B Djahanguiri.   

Abstract

Gastric mucosal ulceration was produced in rats following intraperitoneal injection of indomethacin (40 mg/kg). The incidence of ulcerations was progressively reduced as the bile flow was diverted progressively distal to the ampulla of Vater. It is suggested that bile reflux into the stomach may play a part in the pathogenesis of indomethacin-induced gastric ulceration in rats.

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Year:  1975        PMID： 1115871     DOI： 10.1002/bjs.1800620208

Source DB:  PubMed          Journal:  Br J Surg        ISSN： 0007-1323            Impact factor:   6.939


  5 in total

1.  Mechanisms underlying gastric mucosal damage induced by indomethacin and bile-salts, and the actions of prostaglandins.

Authors:  B J Whittle
Journal:  Br J Pharmacol       Date:  1977-07       Impact factor: 8.739

Review 2.  Surgical progress 1975.

Authors:  H Ellis
Journal:  Postgrad Med J       Date:  1976-03       Impact factor: 2.401

3.  The potentiation of taurocholate-induced rat gastric erosions following parenteral administration of cyclo-oxygenase inhibitors.

Authors:  B J Whittle
Journal:  Br J Pharmacol       Date:  1983-11       Impact factor: 8.739

4.  Antiinflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6-methoxy-2-naphthylacetic acid (6MNA). Comparative studies with indomethacin.

Authors:  R Melarange; C Gentry; C O'Connell; P R Blower; C Neil; A S Kelvin; C D Toseland
Journal:  Dig Dis Sci       Date:  1992-12       Impact factor: 3.199

5.  Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam.

Authors:  Daniel D Hampton; Laura P Hale
Journal:  PLoS One       Date:  2011-08-12       Impact factor: 3.240
  5 in total

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