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Literature DB >> 11158318

Critical role of Caenorhabditis elegans homologs of Cds1 (Chk2)-related kinases in meiotic recombination.

I Oishi¹, K Iwai, Y Kagohashi, H Fujimoto, K Kariya, T Kataoka, H Sawa, H Okano, H Otani, H Yamamura, Y Minami.

Abstract

Although chromosomal segregation at meiosis I is the critical process for genetic reassortment and inheritance, little is known about molecules involved in this process in metazoa. Here we show by utilizing double-stranded RNA (dsRNA)-mediated genetic interference that novel protein kinases (Ce-CDS-1 and Ce-CDS-2) related to Cds1 (Chk2) play an essential role in meiotic recombination in Caenorhabditis elegans. Injection of dsRNA into adult animals resulted in the inhibition of meiotic crossing over and induced the loss of chiasmata at diakinesis in oocytes of F(1) animals. However, electron microscopic analysis revealed that synaptonemal complex formation in pachytene nuclei of the same progeny of injected animals appeared to be normal. Thus, Ce-CDS-1 and Ce-CDS-2 are the first example of Cds1-related kinases that are required for meiotic recombination in multicellular organisms.

Entities: Chemical Disease Gene Species

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Year: 2001 PMID： 11158318 PMCID： PMC99585 DOI： 10.1128/MCB.21.4.1329-1335.2001

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

41 in total

Review 1. RNAi and double-strand RNA.

Authors: P A Sharp
Journal: Genes Dev Date: 1999-01-15 Impact factor: 11.361

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Authors: A Fire; S Xu; M K Montgomery; S A Kostas; S E Driver; C C Mello
Journal: Nature Date: 1998-02-19 Impact factor: 49.962

Review 3. Cell cycle checkpoints: preventing an identity crisis.

Authors: S J Elledge
Journal: Science Date: 1996-12-06 Impact factor: 47.728

4. The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors.

Authors: K Hofmann; P Bucher
Journal: Trends Biochem Sci Date: 1995-09 Impact factor: 13.807

5. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway.

Authors: P Chaturvedi; W K Eng; Y Zhu; M R Mattern; R Mishra; M R Hurle; X Zhang; R S Annan; Q Lu; L F Faucette; G F Scott; X Li; S A Carr; R K Johnson; J D Winkler; B B Zhou
Journal: Oncogene Date: 1999-07-15 Impact factor: 9.867

6. Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system.

Authors: I Oishi; S Takeuchi; R Hashimoto; A Nagabukuro; T Ueda; Z J Liu; T Hatta; S Akira; Y Matsuda; H Yamamura; H Otani; Y Minami
Journal: Genes Cells Date: 1999-01 Impact factor: 1.891

7. Meiotic cells monitor the status of the interhomolog recombination complex.

Authors: L Xu; B M Weiner; N Kleckner
Journal: Genes Dev Date: 1997-01-01 Impact factor: 11.361

Review 8. Sex and the single cell: meiosis in yeast.

Authors: G S Roeder
Journal: Proc Natl Acad Sci U S A Date: 1995-11-07 Impact factor: 11.205

9. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.

Authors: Y Xu; T Ashley; E E Brainerd; R T Bronson; M S Meyn; D Baltimore
Journal: Genes Dev Date: 1996-10-01 Impact factor: 11.361

Critical role of Caenorhabditis elegans homologs of Cds1 (Chk2)-related kinases in meiotic recombination.

Review 1. RNAi and double-strand RNA.

2. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.

Review 3. Cell cycle checkpoints: preventing an identity crisis.

4. The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors.

5. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway.

6. Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system.

7. Meiotic cells monitor the status of the interhomolog recombination complex.

Review 8. Sex and the single cell: meiosis in yeast.

9. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.

10. DUN1 encodes a protein kinase that controls the DNA damage response in yeast.

1. Nuclear reorganization and homologous chromosome pairing during meiotic prophase require C. elegans chk-2.

Review 2. Meiotic recombination in Caenorhabditis elegans.

3. Initiation of Meiotic Development Is Controlled by Three Post-transcriptional Pathways in Caenorhabditis elegans.

4. Meiotic S-phase damage activates recombination without checkpoint arrest.

5. Caenorhabditis elegans Ce-rdh-1/rad-51 functions after double-strand break formation of meiotic recombination.

Review 6. Phospho-Regulation of Meiotic Prophase.

7. The Chromosome Axis Mediates Feedback Control of CHK-2 to Ensure Crossover Formation in C. elegans.