Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Comparison of the cyanogen bromide peptides of insoluble guinea-pig skin and scar collagen.

Literature DB >> 1115796

Comparison of the cyanogen bromide peptides of insoluble guinea-pig skin and scar collagen.

C A Shuttleworth, L Forrest, D S Jackson.

Abstract

Insoluble guinea-pig skin collagen and insoluble dermal scar collagen were cleaved with CNBr and the peptides derived from the alpha1-chain were separated by ion-exchange and molecular-sieve chromatography. Comparison of the peptides from scar collagen with those from skin collagen showed that the former contained more hydroxylysine. Separation of the CNBr peptides showed that this increase in hydroxylysine was found not only in the non-helical regions, but was also seen down the helical portion of the molecule. Separation of the peptides revealed the presence of more peptides in digests of skin collagen than those of scar, and these have been attributed to the presence of Type III collagen in skin, but no evidence was found for the presence of this Type III collagen in dermal scar tissue.

Entities: Chemical Species

Mesh：

Substances：

Year: 1975 PMID： 1115796 DOI： 10.1016/0005-2795(75)90024-0

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

Keyword Cloud
Cited

11 in total

1. Biochemical characteristics and biological significance of the genetically-distinct collagens.

Authors: E J Miller
Journal: Mol Cell Biochem Date: 1976-12-10 Impact factor: 3.396

2. Granulocyte collagenase: selective digestion of type I relative to type III collagen.

Authors: A L Horwitz; A J Hance; R G Crystal
Journal: Proc Natl Acad Sci U S A Date: 1977-03 Impact factor: 11.205

3. The fibrous capsule around mammary implants: An investigation.

Authors: O A Zimman; J M Robles; J C Lee
Journal: Aesthetic Plast Surg Date: 1978-12 Impact factor: 2.326

4. Effect of hepatic injury on prolyl 3-hydroxylase and 4-hydroxylase activities in rat liver and on immunoreactive prolyl 4-hydroxylase concentrations in the liver and serum.

Authors: J Risteli; L Tuderman; K Tryggvason; K I Kivirikko
Journal: Biochem J Date: 1978-01-15 Impact factor: 3.857

5. Intracellular enzymes of collagen biosynthesis in rat liver as a function of age and in hepatic injury induced by dimethylnitrosamine. Changes in prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase and collagen glucosyltransferase activities.

Authors: J Risteli; K I Kivirikko
Journal: Biochem J Date: 1976-08-15 Impact factor: 3.857

Comparison of the cyanogen bromide peptides of insoluble guinea-pig skin and scar collagen.

1. Biochemical characteristics and biological significance of the genetically-distinct collagens.

2. Granulocyte collagenase: selective digestion of type I relative to type III collagen.

3. The fibrous capsule around mammary implants: An investigation.

4. Effect of hepatic injury on prolyl 3-hydroxylase and 4-hydroxylase activities in rat liver and on immunoreactive prolyl 4-hydroxylase concentrations in the liver and serum.

5. Intracellular enzymes of collagen biosynthesis in rat liver as a function of age and in hepatic injury induced by dimethylnitrosamine. Changes in prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase and collagen glucosyltransferase activities.

6. Analysis of cyanogen bromide peptides of type I collagen from a patient with lethal osteogenesis imperfecta.

7. Collagen polymorphism in pathologic human scars.

8. Presence of type III collagen in guinea-pig dermal scar.

9. Increases in type III collagen gene expression and protein synthesis in patients with inguinal hernias.

10. Serum levels of aminoterminal type III procollagen peptide in normal subjects and hepatic fibrosis.