Literature DB >> 1115665

Acute and chronic hyperosmolality. Effects on cerebral amino acids and energy metabolism.

A H Lockwood.   

Abstract

Acute and chronic elevations in osmolality were induced in rats and mice. After 48 and 96 hours of hyperosmolality, rat brain glutamine concentration increased to between 210% of control. This increase may account for 20% of the previously postulated idiogenic osmols that enable the brain to resist volume changes. Cerebral metabolic rates were reduced in the brains of mice made acutely and chronically hyperosmotic in spite of normal levels of adenosine triphosphate and phosphocreatine.

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Year:  1975        PMID： 1115665     DOI： 10.1001/archneur.1975.00490430084018

Source DB:  PubMed          Journal:  Arch Neurol        ISSN： 0003-9942


  7 in total

1.  Central nervous system pH in uremia and the effects of hemodialysis.

Authors:  A I Arieff; R Guisado; S G Massry; V C Lazarowitz
Journal:  J Clin Invest       Date:  1976-08       Impact factor: 14.808

2.  Study of brain electrolytes and organic osmolytes during correction of chronic hyponatremia. Implications for the pathogenesis of central pontine myelinolysis.

Authors:  Y H Lien; J I Shapiro; L Chan
Journal:  J Clin Invest       Date:  1991-07       Impact factor: 14.808

3.  Effects of hypernatremia on organic brain osmoles.

Authors:  Y H Lien; J I Shapiro; L Chan
Journal:  J Clin Invest       Date:  1990-05       Impact factor: 14.808

4.  Effects of acute hyperosmolar NaCl or urea on brain H2O, Na+, K+, carbohydrate, and amino acid metabolism in weanling mice: NaCl induces insulin secretion and hypoglycemia.

Authors:  J H Thurston; R E Hauhart; J A Dirgo; D W Schulz
Journal:  Metab Brain Dis       Date:  1986-06       Impact factor: 3.584

5.  Adaptive decreases in amino acids (taurine in particular), creatine, and electrolytes prevent cerebral edema in chronically hyponatremic mice: rapid correction (experimental model of central pontine myelinolysis) causes dehydration and shrinkage of brain.

Authors:  J H Thurston; R E Hauhart; J S Nelson
Journal:  Metab Brain Dis       Date:  1987-12       Impact factor: 3.584

6.  Changes in blood plasma osmolality and states of mania.

Authors:  C F Baxter; K H Tachiki; S M Blaser; B R Bednar; L F Gosenfeld
Journal:  Neurochem Res       Date:  1981-01       Impact factor: 3.996

7.  Effects of hypernatraemia in the central nervous system and its therapy in rats and rabbits.

Authors:  J C Ayus; D L Armstrong; A I Arieff
Journal:  J Physiol       Date:  1996-04-01       Impact factor: 5.182
  7 in total

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