Peripheral neuropathy in persons with diabetes.

Diabetic peripheral neuropathy (DPN) is a common complication of both type I and II diabetes mellitus. Although the exact cause remains unknown, peripheral neuropathy can cause significant health concerns and decrease the quality of life for those with this condition. Diagnosis of DPN can be made when signs and/or symptoms of peripheral nerve dysfunction are present. Patients with diabetes should be evaluated yearly for DPN with a thorough history and physical examination emphasizing the feet. Strict glycemic control and daily foot care are of utmost importance in the management and prevention of DPN. Pharmacologic therapies for pain control include tricylic antidepressants, anticonvulsants, analgesics, and capsaicin. DPN remains a frequent and serious complication of diabetes mellitus, and left unmanaged, may lead to debilitating consequences of foot ulcers and amputations.