Cytomegalovirus infection as a cause of pseudomembrane colitis: a report of four cases.

Pseudomembranous colitis is very commonly encountered in patients with acquired immune deficiency syndrome (AIDS), and has been characteristically associated with Clostridium difficile infection. We present four cases of AIDS-related diarrhea and pseudomembrane formation on endoscopy with pathologic features consistent with cytomegalovirus (CMV) colitis. Our findings indicate that CMV colitis should be considered in the differential diagnosis of pseudomembranous colitis in immunocompromised patients.