Literature DB >> 11153715

Testosterone decreases CA1 plasticity in vivo in gonadectomized male rats.

C W Harley1, C W Malsbury, A Squires, R A Brown.   

Abstract

Estrogen has been reported to enhance CA1 functional plasticity in adult rats, as measured by the induction of long-term potentiation (LTP). In the present study, the effects of androgens on CA1 LTP were assessed in adult male Sprague-Dawley rats in vivo following peripubertal castration. Castrated rats with cholesterol implants showed significantly greater plasticity, both in degree and duration of potentiation, than castrated rats given testosterone or dihydrotestosterone implants. An LTP paradigm reported to produce decremental LTP in vitro produced nondecremental LTP in androgen-deprived rats, but decremental LTP in androgen-treated rats. These results suggest that androgens, unlike estrogens, act to reduce CA1 plasticity in the adult rat.

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Year:  2000        PMID： 11153715     DOI： 10.1002/1098-1063(2000)10:6<693::AID-HIPO1007>3.0.CO;2-G

Source DB:  PubMed          Journal:  Hippocampus        ISSN： 1050-9631            Impact factor:   3.899


  25 in total

1.  Pubertal exposure to anabolic androgenic steroids increases spine densities on neurons in the limbic system of male rats.

Authors:  R L Cunningham; B J Claiborne; M Y McGinnis
Journal:  Neuroscience       Date:  2007-09-21       Impact factor: 3.590

Review 2.  Role of androgens and the androgen receptor in remodeling of spine synapses in limbic brain areas.

Authors:  Tibor Hajszan; Neil J MacLusky; Csaba Leranth
Journal:  Horm Behav       Date:  2007-12-31       Impact factor: 3.587

3.  Exogenous melatonin reproduces the effects of short day lengths on hippocampal function in male white-footed mice, Peromyscus leucopus.

Authors:  J C Walton; Z Chen; J B Travers; R J Nelson
Journal:  Neuroscience       Date:  2013-06-24       Impact factor: 3.590

4.  Genetic influences on hippocampal volume differ as a function of testosterone level in middle-aged men.

Authors:  Matthew S Panizzon; Richard L Hauger; Lindon J Eaves; Chi-Hua Chen; Anders M Dale; Lisa T Eyler; Bruce Fischl; Christine Fennema-Notestine; Carol E Franz; Michael D Grant; Kristen C Jacobson; Amy J Jak; Michael J Lyons; Sally P Mendoza; Michael C Neale; Elizabeth Prom-Wormley; Larry J Seidman; Ming T Tsuang; Hong Xian; William S Kremen
Journal:  Neuroimage       Date:  2011-10-01       Impact factor: 6.556

5.  Expansion of mossy fibers and CA3 apical dendritic length accompanies the fall in dendritic spine density after gonadectomy in male, but not female, rats.

Authors:  Ari L Mendell; Sarah Atwi; Craig D C Bailey; Dan McCloskey; Helen E Scharfman; Neil J MacLusky
Journal:  Brain Struct Funct       Date:  2016-06-09       Impact factor: 3.270

6.  Photoperiod-mediated impairment of long-term potention and learning and memory in male white-footed mice.

Authors:  J C Walton; Z Chen; Z M Weil; L M Pyter; J B Travers; R J Nelson
Journal:  Neuroscience       Date:  2010-12-08       Impact factor: 3.590

7.  Local N-methyl-d-aspartate receptor antagonism in the prefrontal cortex attenuates spatial cognitive deficits induced by gonadectomy in adult male rats.

Authors:  M N Locklear; S Bhamidipaty; M F Kritzer
Journal:  Neuroscience       Date:  2014-12-27       Impact factor: 3.590

8.  Interactive effects of testosterone and cortisol on hippocampal volume and episodic memory in middle-aged men.

Authors:  Matthew S Panizzon; Richard L Hauger; Hong Xian; Kristen Jacobson; Michael J Lyons; Carol E Franz; William S Kremen
Journal:  Psychoneuroendocrinology       Date:  2018-03-09       Impact factor: 4.905

9.  Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4.

Authors:  Jan Hendrik Sitz; Marcel Tigges; Karsten Baumgärtel; Leonid G Khaspekov; Beat Lutz
Journal:  Mol Cell Biol       Date:  2004-07       Impact factor: 4.272

10.  Testosterone depletion in adult male rats increases mossy fiber transmission, LTP, and sprouting in area CA3 of hippocampus.

Authors:  Vanessa A Skucas; Aine M Duffy; Lauren C Harte-Hargrove; Alejandra Magagna-Poveda; Thomas Radman; Goutam Chakraborty; Charles E Schroeder; Neil J MacLusky; Helen E Scharfman
Journal:  J Neurosci       Date:  2013-02-06       Impact factor: 6.167
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