Literature DB >> 11152935

Heparinase I acts on a synthetic heparin pentasaccharide corresponding to the antithrombin III binding site.

G Yu1, L LeBrun, N S Gunay, D Hoppensteadt, J M Walenga, J Fareed, R J Linhardt.   

Abstract

A synthetic pentasaccharide, containing an intact antithrombin III (ATIII) binding site that is in clinical studies a specific antifactor Xa agent, serves as a substrate for a heparin lyase (heparinase I, EC 4.2.2.7) from Flavobacterium heparinum. Heparinase I, currently being assessed as a heparin reversal agent, also reverses the antifactor Xa activity of this synthetic pentasaccharide by breaking it down to inactive disaccharide and trisaccharide products.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 11152935     DOI： 10.1016/s0049-3848(00)00368-6

Source DB:  PubMed          Journal:  Thromb Res        ISSN： 0049-3848            Impact factor:   3.944


  8 in total

1.  Analysis of 3-O-sulfo group-containing heparin tetrasaccharides in heparin by liquid chromatography-mass spectrometry.

Authors:  Guoyun Li; Bo Yang; Lingyun Li; Fuming Zhang; Changhu Xue; Robert J Linhardt
Journal:  Anal Biochem       Date:  2014-03-28       Impact factor: 3.365

2.  Dromedary glycosaminoglycans: molecular characterization of camel lung and liver heparan sulfate.

Authors:  Mohammad Warda; Robert J Linhardt
Journal:  Comp Biochem Physiol B Biochem Mol Biol       Date:  2005-11-17       Impact factor: 2.231

3.  NMR methods to monitor the enzymatic depolymerization of heparin.

Authors:  John F K Limtiaco; Szabolcs Beni; Christopher J Jones; Derek J Langeslay; Cynthia K Larive
Journal:  Anal Bioanal Chem       Date:  2010-09-04       Impact factor: 4.142

4.  Heparin mapping using heparin lyases and the generation of a novel low molecular weight heparin.

Authors:  Zhongping Xiao; Britney R Tappen; Mellisa Ly; Wenjing Zhao; Lauren P Canova; Huashi Guan; Robert J Linhardt
Journal:  J Med Chem       Date:  2010-12-17       Impact factor: 7.446

5.  A competitive binding study of chemokine, sulfated receptor, and glycosaminoglycan interactions by nano-electrospray ionization mass spectrometry.

Authors:  Connie H Jen; Julie A Leary
Journal:  Anal Biochem       Date:  2010-08-07       Impact factor: 3.365

6.  Mass Spectrometry for the Analysis of Highly Charged Sulfated Carbohydrates.

Authors:  Lianli Chi; Jonathan Amster; Robert J Linhardt
Journal:  Curr Anal Chem       Date:  2005       Impact factor: 2.374

Review 7.  [Old and new anticoagulants. Antidotes and measures for acute hemorrhaging and urgent interventions].

Authors:  M Lancé; B Stessel; K Hamulyák; M A Marcus
Journal:  Anaesthesist       Date:  2010-01       Impact factor: 1.041

8.  Isolation and characterization of heparan sulfate from various murine tissues.

Authors:  Mohamad Warda; Toshihiko Toida; Fuming Zhang; Peilong Sun; Eva Munoz; Jin Xie; Robert J Linhardt
Journal:  Glycoconj J       Date:  2006-11       Impact factor: 2.916
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.