Literature DB >> 11152514

Identification of two prion protein regions that modify scrapie incubation time.

S Supattapone1, T Muramoto, G Legname, I Mehlhorn, F E Cohen, S J DeArmond, S B Prusiner, M R Scott.   

Abstract

A series of prion transmission experiments was performed in transgenic (Tg) mice expressing either wild-type, chimeric, or truncated prion protein (PrP) molecules. Following inoculation with Rocky Mountain Laboratory (RML) murine prions, scrapie incubation times for Tg(MoPrP)4053, Tg(MHM2)294/Prnp(0/0), and Tg(MoPrP, Delta23-88)9949/Prnp(0/0) mice were approximately 50, 120, and 160 days, respectively. Similar scrapie incubation times were obtained after inoculation of these lines of Tg mice with either MHM2(MHM2(RML)) or MoPrP(Delta23-88)(RML) prions, excluding the possibility that sequence-dependent transmission barriers could account for the observed differences. Tg(MHM2)294/Prnp(0/0) mice displayed prolonged scrapie incubation times with four different strains of murine prions. These data provide evidence that the N terminus of MoPrP and the chimeric region of MHM2 PrP (residues 108 through 111) both influence the inherent efficiency of prion propagation.

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Year:  2001        PMID： 11152514      PMCID： PMC114047          DOI： 10.1128/JVI.75.3.1408-1413.2001

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  34 in total

1.  Eight prion strains have PrP(Sc) molecules with different conformations.

Authors:  J Safar; H Wille; V Itri; D Groth; H Serban; M Torchia; F E Cohen; S B Prusiner
Journal:  Nat Med       Date:  1998-10       Impact factor: 53.440

2.  A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform.

Authors:  D Peretz; R A Williamson; Y Matsunaga; H Serban; C Pinilla; R B Bastidas; R Rozenshteyn; T L James; R A Houghten; F E Cohen; S B Prusiner; D R Burton
Journal:  J Mol Biol       Date:  1997-10-31       Impact factor: 5.469

Review 3.  Prion protein biology.

Authors:  S B Prusiner; M R Scott; S J DeArmond; F E Cohen
Journal:  Cell       Date:  1998-05-01       Impact factor: 41.582

4.  Mice with gene targetted prion protein alterations show that Prnp, Sinc and Prni are congruent.

Authors:  R C Moore; J Hope; P A McBride; I McConnell; J Selfridge; D W Melton; J C Manson
Journal:  Nat Genet       Date:  1998-02       Impact factor: 38.330

5.  Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform.

Authors:  T L James; H Liu; N B Ulyanov; S Farr-Jones; H Zhang; D G Donne; K Kaneko; D Groth; I Mehlhorn; S B Prusiner; F E Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-16       Impact factor: 11.205

6.  Heritable disorder resembling neuronal storage disease in mice expressing prion protein with deletion of an alpha-helix.

Authors:  T Muramoto; S J DeArmond; M Scott; G C Telling; F E Cohen; S B Prusiner
Journal:  Nat Med       Date:  1997-07       Impact factor: 53.440

7.  Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible.

Authors:  D G Donne; J H Viles; D Groth; I Mehlhorn; T L James; F E Cohen; S B Prusiner; P E Wright; H J Dyson
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-09       Impact factor: 11.205

Review 8.  To what extent is strain variation evidence for an independent genome in the agent of the transmissible spongiform encephalopathies?

Authors:  R M Ridley; H F Baker
Journal:  Neurodegeneration       Date:  1996-09

9.  Mapping the prion protein using recombinant antibodies.

Authors:  R A Williamson; D Peretz; C Pinilla; H Ball; R B Bastidas; R Rozenshteyn; R A Houghten; S B Prusiner; D R Burton
Journal:  J Virol       Date:  1998-11       Impact factor: 5.103

Review 10.  Prions.

Authors:  S B Prusiner
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-10       Impact factor: 11.205
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  48 in total

1.  Domain organization and structure-function relationship of the HET-s prion protein of Podospora anserina.

Authors:  Axelle Balguerie; Suzana Dos Reis; Christiane Ritter; Stéphane Chaignepain; Bénédicte Coulary-Salin; Vincent Forge; Katell Bathany; Ioan Lascu; Jean-Marie Schmitter; Roland Riek; Sven J Saupe
Journal:  EMBO J       Date:  2003-05-01       Impact factor: 11.598

Review 2.  Transgenesis applied to transmissible spongiform encephalopathies.

Authors:  Jean-Luc Vilotte; Hubert Laude
Journal:  Transgenic Res       Date:  2002-12       Impact factor: 2.788

3.  The mechanism of internalization of glycosylphosphatidylinositol-anchored prion protein.

Authors:  Claire Sunyach; Angela Jen; Juelin Deng; Kathleen T Fitzgerald; Yveline Frobert; Jacques Grassi; Mary W McCaffrey; Roger Morris
Journal:  EMBO J       Date:  2003-07-15       Impact factor: 11.598

4.  Conformational transformation and selection of synthetic prion strains.

Authors:  Sina Ghaemmaghami; Joel C Watts; Hoang-Oanh Nguyen; Shigenari Hayashi; Stephen J DeArmond; Stanley B Prusiner
Journal:  J Mol Biol       Date:  2011-08-04       Impact factor: 5.469

5.  Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities.

Authors:  Roberto Chiesa; Pedro Piccardo; Emiliano Biasini; Bernardino Ghetti; David A Harris
Journal:  J Neurosci       Date:  2008-12-03       Impact factor: 6.167

6.  Convergent replication of mouse synthetic prion strains.

Authors:  Sina Ghaemmaghami; David W Colby; Hoang-Oanh B Nguyen; Shigenari Hayashi; Abby Oehler; Stephen J DeArmond; Stanley B Prusiner
Journal:  Am J Pathol       Date:  2013-03       Impact factor: 4.307

7.  Creationism and evolutionism in prions.

Authors:  Pierluigi Gambetti
Journal:  Am J Pathol       Date:  2013-02-01       Impact factor: 4.307

8.  Abbreviated incubation times for human prions in mice expressing a chimeric mouse-human prion protein transgene.

Authors:  Carsten Korth; Kiyotoshi Kaneko; Darlene Groth; Norbert Heye; Glenn Telling; James Mastrianni; Piero Parchi; Pierluigi Gambetti; Robert Will; James Ironside; Cornelia Heinrich; Patrick Tremblay; Stephen J DeArmond; Stanley B Prusiner
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-08       Impact factor: 11.205

9.  Guinea Pig Prion Protein Supports Rapid Propagation of Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease Prions.

Authors:  Joel C Watts; Kurt Giles; Daniel J Saltzberg; Brittany N Dugger; Smita Patel; Abby Oehler; Sumita Bhardwaj; Andrej Sali; Stanley B Prusiner
Journal:  J Virol       Date:  2016-10-14       Impact factor: 5.103

10.  Protease-sensitive synthetic prions.

Authors:  David W Colby; Rachel Wain; Ilia V Baskakov; Giuseppe Legname; Christina G Palmer; Hoang-Oanh B Nguyen; Azucena Lemus; Fred E Cohen; Stephen J DeArmond; Stanley B Prusiner
Journal:  PLoS Pathog       Date:  2010-01-22       Impact factor: 6.823
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