Ligand substituent effects on asymmetric induction. Effect Of structural variations of the DIOP ligand on the Rh-catalyzed asymmetric hydrogenation of enamides

Substituent changes in the ligand (L) backbone and the chelating phosphorus atoms of the classical DIOP ligand result in dramatic changes in the enantioselectivity of Rh(+)L-catalyzed enamide hydrogenations.