Literature DB >> 11149573

Classification of premalignant and malignant lesions developing in the rat mammary gland after injection of sexually immature rats with 1-methyl-1-nitrosourea.

H J Thompson1, M Singh, J McGinley.   

Abstract

Premalignant and malignant stages of mammary carcinogenesis can be rapidly induced by injecting female rats i.p. with 1-methyl-1-nitrosourea (MNU)3 at 21 days of age. In this paper, the characteristics of this model are briefly reviewed and the histology of the lesions induced is presented and compared to those that occur in humans. Malignant mammary lesions induced in rats injected with MNU at 21 days of age are compared with the lesions that develop when MNU is administered to 50-day-old female rats.

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Year:  2000        PMID： 11149573     DOI： 10.1023/a:1026495322596

Source DB:  PubMed          Journal:  J Mammary Gland Biol Neoplasia        ISSN： 1083-3021            Impact factor:   2.673


  12 in total

1.  Effect of energy restriction on the expression of cyclin D1 and p27 during premalignant and malignant stages of chemically induced mammary carcinogenesis.

Authors:  Z Zhu; W Jiang; H J Thompson
Journal:  Mol Carcinog       Date:  1999-04       Impact factor: 4.784

Review 2.  Comparative study of human and rat mammary tumorigenesis.

Authors:  J Russo; B A Gusterson; A E Rogers; I H Russo; S R Wellings; M J van Zwieten
Journal:  Lab Invest       Date:  1990-03       Impact factor: 5.662

Review 3.  Pathology of tumours in laboratory animals. Tumours of the rat. Tumours of the mammary gland.

Authors:  J Russo; I H Russo; A E Rogers; M J van Zwieten; B Gusterson
Journal:  IARC Sci Publ       Date:  1990

4.  Reduction in the frequency of activated ras oncogenes in rat mammary carcinomas with increasing N-methyl-N-nitrosourea doses or increasing prolactin levels.

Authors:  R Zhang; J D Haag; M N Gould
Journal:  Cancer Res       Date:  1990-07-15       Impact factor: 12.701

5.  Ovarian hormone dependence of pre-malignant and malignant mammary gland lesions induced in pre-pubertal rats by 1-methyl-1-nitrosourea.

Authors:  H J Thompson; J McGinley; K Rothhammer; M Singh
Journal:  Carcinogenesis       Date:  1998-03       Impact factor: 4.944

Review 6.  Immunohistochemical detection and gene amplification of cyclin D1 in mammary infiltrating ductal carcinoma.

Authors:  H F Frierson; M J Gaffey; L R Zukerberg; A Arnold; M E Williams
Journal:  Mod Pathol       Date:  1996-07       Impact factor: 7.842

7.  Effect of carcinogen dose and age at administration on induction of mammary carcinogenesis by 1-methyl-1-nitrosourea.

Authors:  H J Thompson; H Adlakha; M Singh
Journal:  Carcinogenesis       Date:  1992-09       Impact factor: 4.944

8.  Rapid induction of mammary intraductal proliferations, ductal carcinoma in situ and carcinomas by the injection of sexually immature female rats with 1-methyl-1-nitrosourea.

Authors:  H J Thompson; J N McGinley; K Rothhammer; M Singh
Journal:  Carcinogenesis       Date:  1995-10       Impact factor: 4.944

9.  Lifetime dose-response relationships for mammary tumor induction by a single administration of N-methyl-N-nitrosourea.

Authors:  D L McCormick; C B Adamowski; A Fiks; R C Moon
Journal:  Cancer Res       Date:  1981-05       Impact factor: 12.701

10.  Deregulated expression of p27(Kip1) in human breast cancers.

Authors:  A Sgambato; Y J Zhang; N Arber; H Hibshoosh; Y Doki; M Ciaparrone; R M Santella; A Cittadini; I B Weinstein
Journal:  Clin Cancer Res       Date:  1997-10       Impact factor: 12.531
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  16 in total

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2.  Peripheral tumors alter neuroinflammatory responses to lipopolysaccharide in female rats.

Authors:  Leah M Pyter; Sarah El Mouatassim Bih; Husain Sattar; Brian J Prendergast
Journal:  Brain Res       Date:  2014-01-20       Impact factor: 3.252

3.  Inherent aerobic capacity-dependent differences in breast carcinogenesis.

Authors:  Henry J Thompson; Lee W Jones; Lauren G Koch; Steven L Britton; Elizabeth S Neil; John N McGinley
Journal:  Carcinogenesis       Date:  2017-09-01       Impact factor: 4.944

4.  Effects of energy restriction and wheel running on mammary carcinogenesis and host systemic factors in a rat model.

Authors:  Zongjian Zhu; Weiqin Jiang; Jarrod H Zacher; Elizabeth S Neil; John N McGinley; Henry J Thompson
Journal:  Cancer Prev Res (Phila)       Date:  2012-01-13

5.  Effects of short-term estrogen treatment on the progression of N-methyl-N-nitrosourea-induced premalignant mammary lesions in female Lewis rats.

Authors:  Takashi Yuri; Yen-Chang Lai; Sayaka Kanematsu; Maki Kuwata; Katsuhiko Yoshizawa; Airo Tsubura
Journal:  Med Mol Morphol       Date:  2011-09-16       Impact factor: 2.309

6.  Mammary tumors induce select cognitive impairments.

Authors:  Leah M Pyter; Sally F Cochrane; Rebecca L Ouwenga; Priyesh N Patel; Vanessa Pineros; Brian J Prendergast
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7.  Estrous cycle regulation of mammary epithelial cell proliferation, differentiation, and death in the Sprague-Dawley rat: a model for investigating the role of estrous cycling in mammary carcinogenesis.

Authors:  P Schedin; T Mitrenga; M Kaeck
Journal:  J Mammary Gland Biol Neoplasia       Date:  2000-04       Impact factor: 2.673

8.  A combination of green tea extract, specific nutrient mixture and quercetin: An effective intervention treatment for the regression of N-methyl-N-nitrosourea (MNU)-induced mammary tumors in Wistar rats.

Authors:  Anup Kale; Sonia Gawande; Swati Kotwal; Shrirang Netke; M Waheed Roomi; Vadim Ivanov; Aleksandra Niedzwiecki; Matthias Rath
Journal:  Oncol Lett       Date:  2010-03-01       Impact factor: 2.967

9.  Intraductal administration of a polymeric nanoparticle formulation of curcumin (NanoCurc) significantly attenuates incidence of mammary tumors in a rodent chemical carcinogenesis model: Implications for breast cancer chemoprevention in at-risk populations.

Authors:  Yong Soon Chun; Savita Bisht; Venugopal Chenna; Dipankar Pramanik; Takahiro Yoshida; Seung-Mo Hong; Roeland F de Wilde; Zhe Zhang; David L Huso; Ming Zhao; Michelle A Rudek; Vered Stearns; Anirban Maitra; Saraswati Sukumar
Journal:  Carcinogenesis       Date:  2012-07-25       Impact factor: 4.944

10.  Defining the role of histone deacetylases in the inhibition of mammary carcinogenesis by dietary energy restriction (DER): effects of suberoylanilide hydroxamic acid (SAHA) and DER in a rat model.

Authors:  Zongjian Zhu; Weiqin Jiang; John N McGinley; Henry J Thompson
Journal:  Cancer Prev Res (Phila)       Date:  2013-01-30
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