Literature DB >> 11149250

The correlation between cancer incidence and kava consumption.

G G Steiner.   

Abstract

BACKGROUND: A number of countries in the South Pacific have very low cancer incidence. In spite of a high percentage of the population habituated to tobacco, the cancer incidence in countries such as Vanuatu and Fiji experience age-standardized cancer incidence in the 70's. A number of studies have noted the low cancer incidence in these countries and have postulated that a dietary chemopreventive agent might be responsible.
METHODS: The cancer incidence studies for the Pacific Islands were completed in the 1980's. During this time period accurate records allow for a calculation of local kava consumption. This study compares the cancer incidence for a number of Pacific Island Nations with local kava consumption. RESULTS/
CONCLUSIONS: The data indicates that the more kava consumed by a population the lower the cancer incidence for that population. The data suggests there is a close inverse relationship between cancer incidence and kava consumption.

Entities:  

Mesh:

Year:  2000        PMID: 11149250

Source DB:  PubMed          Journal:  Hawaii Med J        ISSN: 0017-8594


  28 in total

1.  Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth.

Authors:  Yaxiong Tang; Xuesen Li; Zhongbo Liu; Anne R Simoneau; Jun Xie; Xiaolin Zi
Journal:  Int J Cancer       Date:  2010-10-15       Impact factor: 7.396

2.  Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice.

Authors:  Pablo Leitzman; Sreekanth C Narayanapillai; Silvia Balbo; Bo Zhou; Pramod Upadhyaya; Ahmad Ali Shaik; M Gerard O'Sullivan; Stephen S Hecht; Junxuan Lu; Chengguo Xing
Journal:  Cancer Prev Res (Phila)       Date:  2014-01

3.  Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines.

Authors:  Toshinori Sakai; Ramez N Eskander; Yi Guo; Kap Jung Kim; Jason Mefford; Justin Hopkins; Nitin N Bhatia; Xiaolin Zi; Bang H Hoang
Journal:  J Orthop Res       Date:  2011-12-29       Impact factor: 3.494

4.  The Impact of One-week Dietary Supplementation with Kava on Biomarkers of Tobacco Use and Nitrosamine-based Carcinogenesis Risk among Active Smokers.

Authors:  Yi Wang; Sreekanth C Narayanapillai; Katelyn M Tessier; Lori G Strayer; Pramod Upadhyaya; Qi Hu; Rick Kingston; Ramzi G Salloum; Junxuan Lu; Stephen S Hecht; Dorothy K Hatsukami; Naomi Fujioka; Chengguo Xing
Journal:  Cancer Prev Res (Phila)       Date:  2020-02-26

Review 5.  Cancer epidemiology in the pacific islands - past, present and future.

Authors:  Malcolm A Moore; Francine Baumann; Sunia Foliaki; Marc T Goodman; Robert Haddock; Roger Maraka; Josefa Koroivueta; David Roder; Thomas Vinit; Helen J D Whippy; Tomotaka Sobue
Journal:  Asian Pac J Cancer Prev       Date:  2010

6.  Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity.

Authors:  Ahmad Ali Shaik; David Lee Hermanson; Chengguo Xing
Journal:  Bioorg Med Chem Lett       Date:  2009-08-06       Impact factor: 2.823

7.  Effects of the kava chalcone flavokawain A differ in bladder cancer cells with wild-type versus mutant p53.

Authors:  Yaxiong Tang; Anne R Simoneau; Jun Xie; Babbak Shahandeh; Xiaolin Zi
Journal:  Cancer Prev Res (Phila)       Date:  2008-11

8.  Kava, a tonic for relieving the irrational development of natural preventive agents.

Authors:  Rajesh Agarwal; Gagan Deep
Journal:  Cancer Prev Res (Phila)       Date:  2008-11

9.  Kava components down-regulate expression of AR and AR splice variants and reduce growth in patient-derived prostate cancer xenografts in mice.

Authors:  Xuesen Li; Zhongbo Liu; Xia Xu; Christopher A Blair; Zheng Sun; Jun Xie; Michael B Lilly; Xiaolin Zi
Journal:  PLoS One       Date:  2012-02-09       Impact factor: 3.240

10.  Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis.

Authors:  Tao Ji; Carol Lin; Lauren S Krill; Ramez Eskander; Yi Guo; Xiaolin Zi; Bang H Hoang
Journal:  Mol Cancer       Date:  2013-06-10       Impact factor: 27.401

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