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Literature DB >> 11148524

Evaluation of primary hemostasis in neonates with a new in vitro platelet function analyzer.

S J Israels¹, T Cheang, E M McMillan-Ward, M Cheang.

Abstract

With the use of the PFA-100 platelet function analyzer to evaluate primary hemostasis in whole blood, measured as closure time (CT), neonates had shorter CTs than members of an adult control group. Multivariate analysis of measures that contribute to primary hemostasis showed that higher hematocrits and increased ristocetin cofactor activity were the best correlates for CTs of cord blood. These 2 factors may also enhance primary hemostasis in vivo and compensate for the impaired platelet function of the newborn.

Entities: Chemical

Mesh：

Substances：
von Willebrand Factor

Year: 2001 PMID： 11148524 DOI： 10.1067/mpd.2001.109794

Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406

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Cited

21 in total

1. Antithrombotic therapy in neonates and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Authors: Paul Monagle; Anthony K C Chan; Neil A Goldenberg; Rebecca N Ichord; Janna M Journeycake; Ulrike Nowak-Göttl; Sara K Vesely
Journal: Chest Date: 2012-02 Impact factor: 9.410

Evaluation of primary hemostasis in neonates with a new in vitro platelet function analyzer.

1. Antithrombotic therapy in neonates and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

2. Developmental changes in soluble CD40 ligand.

Review 3. Coagulopathy after severe pediatric trauma.

Review 4. Antiplatelet therapy in pediatric cardiovascular patients.

5. Effects of in vitro adult platelet transfusions on neonatal hemostasis.

Review 6. Antithrombotic drug treatment of pediatric patients with ischemic stroke.

Review 7. Neonatal platelet physiology and implications for transfusion.

Review 8. Platelet Transfusions in the Neonatal Intensive Care Unit.

9. Assessment of neonatal platelet adhesion, activation, and aggregation.

Review 10. Neonatal platelets: mediators of primary hemostasis in the developing hemostatic system.