| Literature DB >> 11148248 |
B Stankoff1, A Tourbah, S Suarez, E Turell, J L Stievenart, C Payan, A Coutellier, S Herson, L Baril, F Bricaire, V Calvez, E A Cabanis, L Lacomblez, C Lubetzki.
Abstract
To assess the impact of highly active antiretroviral therapy (HAART) on AIDS-associated cognitive impairment, 22 patients with AIDS with (n = 11) and without (n = 11) cognitive deficit were evaluated clinically and by MRS every 3 months for 9 months. Nineteen patients were on HAART at study entry, 21 after 2 months. Cognitively impaired patients presented with a subcorticofrontal deficit and decreased N-acetyl-aspartate in frontal white matter. These clinical and metabolic abnormalities reversed partially on HAART, whereas they remained within normal limits in cognitively unimpaired patients.Entities:
Mesh：
Year: 2001 PMID： 11148248 DOI： 10.1212/wnl.56.1.112
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910