Literature DB >> 11146647

The spindle: a dynamic assembly of microtubules and motors.

T Wittmann1, A Hyman, A Desai.   

Abstract

In all eukaryotes, a microtubule-based structure known as the spindle is responsible for accurate chromosome segregation during cell division. Spindle assembly and function require localized regulation of microtubule dynamics and the activity of a variety of microtubule-based motor proteins. Recent work has begun to uncover the molecular mechanisms that underpin this process. Here we describe the structural and dynamic properties of the spindle, and introduce the current concepts regarding how a bipolar spindle is assembled and how it functions to segregate chromosomes.

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Year:  2001        PMID： 11146647     DOI： 10.1038/35050669

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  165 in total

1.  A novel plant kinesin-related protein specifically associates with the phragmoplast organelles.

Authors:  Y R Lee; H M Giang; B Liu
Journal:  Plant Cell       Date:  2001-11       Impact factor: 11.277

2.  Targeted new membrane addition in the cleavage furrow is a late, separate event in cytokinesis.

Authors:  C B Shuster; D R Burgess
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-12       Impact factor: 11.205

3.  A kinesin mutant with an atypical bipolar spindle undergoes normal mitosis.

Authors:  A I Marcus; W Li; H Ma; R J Cyr
Journal:  Mol Biol Cell       Date:  2003-04       Impact factor: 4.138

4.  Microtubule flux and sliding in mitotic spindles of Drosophila embryos.

Authors:  Ingrid Brust-Mascher; Jonathan M Scholey
Journal:  Mol Biol Cell       Date:  2002-11       Impact factor: 4.138

5.  Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos.

Authors:  Peter Askjaer; Vincent Galy; Eva Hannak; Iain W Mattaj
Journal:  Mol Biol Cell       Date:  2002-12       Impact factor: 4.138

6.  Dynamics of microtubule asters in microfabricated chambers: the role of catastrophes.

Authors:  Cendrine Faivre-Moskalenko; Marileen Dogterom
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-16       Impact factor: 11.205

7.  A small heat shock/alpha-crystallin protein from encysted Artemia embryos suppresses tubulin denaturation.

Authors:  Rossalyn M Day; Jagdish S Gupta; Thomas H MacRae
Journal:  Cell Stress Chaperones       Date:  2003       Impact factor: 3.667

8.  The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase.

Authors:  Jae H Choi; Paula G Bertram; Ryan Drenan; John Carvalho; Heather H Zhou; X F Steven Zheng
Journal:  EMBO Rep       Date:  2002-09-13       Impact factor: 8.807

9.  Plk phosphorylation regulates the microtubule-stabilizing protein TCTP.

Authors:  Frederic R Yarm
Journal:  Mol Cell Biol       Date:  2002-09       Impact factor: 4.272

10.  Phase II study to assess the efficacy, safety and tolerability of the mitotic spindle kinesin inhibitor AZD4877 in patients with recurrent advanced urothelial cancer.

Authors:  Robert Jones; Jacqueline Vuky; Tony Elliott; Graham Mead; José Angel Arranz; John Chester; Simon Chowdhury; Arkadiusz Z Dudek; Volker Müller-Mattheis; Marc-Oliver Grimm; Jürgen E Gschwend; Christian Wülfing; Peter Albers; Jianguo Li; Anna Osmukhina; Jeffrey Skolnik; Gary Hudes
Journal:  Invest New Drugs       Date:  2013-01-18       Impact factor: 3.850
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