| Literature DB >> 11146225 |
E Jonsson1, L E Friberg, M O Karlsson, S B Hassan, P Nygren, J Kristensen, B Tholander, L Binderup, R Larsson.
Abstract
Fresh human tumour cells from patients with ovarian cancer and chronic lymphocytic leukaemia were cultured in semipermeable hollow fibres. The fibres were implanted on immunocompetent rats, which were treated with the cyanoguanidine N-(4-chlorophenoxyhexyl)-N'-cyano-N"-4-pyridylguanidine (CHS 828). CHS 828 showed high antitumour activity against all eight tumour samples; the fibres from control animals had a mean net growth of 73% while CHS 828 treatment induced a 37% mean reduction of cell density, without observable haematological toxicity. The results show a feasibility of using tumour cells directly from patients in the hollow-fibre rat model.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11146225 DOI： 10.1016/s0304-3835(00)00661-3
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679