Literature DB >> 11144963

Treatment of carbon tetrachloride and phenobarbital-induced chronic liver failure with intrasplenic hepatocyte transplantation.

N Kobayashi1, M Ito, J Nakamura, J Cai, J M Hammel, I J Fox.   

Abstract

Hepatocyte transplantation (HTx) has been shown to improve the survival of laboratory animals with experimentally induced acute liver failure and to ameliorate the physiologic abnormalities associated with liver-based metabolic deficiencies. However, the role of HTx in the treatment of liver cirrhosis (LC) has not been adequately studied. In order to address this issue, HTx was performed in rats following induction of stable LC using phenobarbital (PhB) and carbon tetrachloride (CCl4). Intrasplenic transplantation of 50 x 10(6) primary hepatocytes could significantly improve liver functions and prolong the survival of rats with irreversible, decompensated LC.

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Year:  2000        PMID： 11144963     DOI： 10.1177/096368970000900512

Source DB:  PubMed          Journal:  Cell Transplant        ISSN： 0963-6897            Impact factor:   4.064


  7 in total

1.  Cell therapeutic options in liver diseases: cell types, medical devices and regulatory issues.

Authors:  Andreas K Nussler; Katrin Zeilinger; Lilianna Schyschka; Sabrina Ehnert; Jörg C Gerlach; Xueying Yan; Serene M L Lee; Maren Ilowski; Wolfgang E Thasler; Thomas S Weiss
Journal:  J Mater Sci Mater Med       Date:  2011-04-03       Impact factor: 3.896

2.  Characteristics of rat bone marrow cells differentiated into a liver cell lineage and dynamics of the transplanted cells in the injured liver.

Authors:  Kazuo Okumoto; Takafumi Saito; Hiroaki Haga; Etsuko Hattori; Rika Ishii; Tetsuru Karasawa; Akihiko Suzuki; Keiko Misawa; Mai Sanjo; Jun-itsu Ito; Kazuhiko Sugahara; Koji Saito; Hitoshi Togashi; Sumio Kawata
Journal:  J Gastroenterol       Date:  2006-01       Impact factor: 7.527

3.  Enhanced sedative efficacy and delayed recovery in propofol anesthesia in a rat model of hepatic cirrhosis.

Authors:  Xuexin Chen; Rui Yan; Zhixia Bai; Hanxiang Ma
Journal:  Int J Clin Exp Med       Date:  2015-04-15

4.  Restrictive model of compensated carbon tetrachloride-induced cirrhosis in rats.

Authors:  Jean-Marc Regimbeau; David Fuks; Niaz Kohneh-Shahri; Benoît Terris; Olivier Soubrane
Journal:  World J Gastroenterol       Date:  2008-12-07       Impact factor: 5.742

Review 5.  An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure.

Authors:  María-Jesús Tuñón; Marcelino Alvarez; Jesús-M Culebras; Javier González-Gallego
Journal:  World J Gastroenterol       Date:  2009-07-07       Impact factor: 5.742

6.  The history and use of human hepatocytes for the treatment of liver diseases: the first 100 patients.

Authors:  Marc C Hansel; Roberto Gramignoli; Kristen J Skvorak; Kenneth Dorko; Fabio Marongiu; William Blake; Julio Davila; Stephen C Strom
Journal:  Curr Protoc Toxicol       Date:  2014-11-06

7.  Intrasplenic transplantation of bioencapsulated mesenchymal stem cells improves the recovery rates of 90% partial hepatectomized rats.

Authors:  Zun Chang Liu; Thomas Ming Swi Chang
Journal:  Stem Cells Int       Date:  2012-11-28       Impact factor: 5.443
  7 in total

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