Literature DB >> 1114316

Stroke in rats produced by carotid injection of sodium arachidonate.

T W Furlow, N H Bass.   

Abstract

Unilateral cerebrovascular occlusion was produced in heparinized rats within 60 seconds after an injection of sodium arachidonate (in doses exceeding 0.45 milligram per kilogram) into the carotid artery. Electroencephalographic activity over the affected cerebral hemisphere was suppressed, and cerebral blood flow decreased by half. Microscopic examination revealed complete obstruction of the hemispheric microcirculation by platelet aggregates.

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Year:  1975        PMID: 1114316     DOI: 10.1126/science.1114316

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  3 in total

Review 1.  Immediate and long range effects of the uptake of increased amounts of arachidonic acid.

Authors:  O Adam
Journal:  Clin Investig       Date:  1992-09

2.  A model for the study of stroke using the rat. Surgical ligation of the middle cerebral artery in the rat.

Authors:  R G Robinson
Journal:  Am J Pathol       Date:  1981-07       Impact factor: 4.307

3.  Vasoconstrictor response to arachidonic acid in the isolated hind limb of the dog.

Authors:  T M Fitzpatrick; M Johnson; P A Kot; P W Ramwell; J C Rose
Journal:  Br J Pharmacol       Date:  1977-02       Impact factor: 8.739

  3 in total

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