Literature DB >> 1114315

Mezerein: antileukemic principle isolated from Daphne mezereum L.

S M Kupchan, R L Baxter.   

Abstract

An alcohol-water extract of Daphne mezereum L., a plant widely used in folk medicine for treating cancers, showed antileukemic activity against the P-388 lymphocytic leukemia in mice. Systematic fractionation of the extract has led to isolation and characterization of mezerein as the principal antileukemic component.

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Year:  1975        PMID： 1114315     DOI： 10.1126/science.1114315

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  12 in total

1.  In vitro antileukaemic activity of extracts from Daphne gnidium leaves against sensitive and multidrug resistant K562/R7 cells.

Authors:  Fadwa Chaabane; Mounira Krifa; Eva Matera; Amira Loussaeif; Marie-Geneviève Dijoux-Franca; Kamel Ghedira; Charles Dumontet; Leila Chekir-Ghedira
Journal:  Tumour Biol       Date:  2014-06-06

2.  An inhibitory role for the protein kinase C pathway in ovarian steroidogenesis. Studies with cultured swine granulosa cells.

Authors:  J D Veldhuis; L M Demers
Journal:  Biochem J       Date:  1986-11-01       Impact factor: 3.857

3.  New tigliane and daphnane derivatives from Pimelea prostrata and Pimelea simplex.

Authors:  S Zayed; A Hafez; W Adolf; E Hecker
Journal:  Experientia       Date:  1977-12-15

4.  Factors which disorganize microtubules or microfilaments increase the frequency of cell transformation by polyoma virus.

Authors:  R Seif
Journal:  J Virol       Date:  1980-11       Impact factor: 5.103

5.  Stimulation of human gamma interferon production by diterpene esters.

Authors:  Y K Yip; R H Pang; J D Oppenheim; M S Nachbar; D Henriksen; I Zerebeckyj-Eckhardt; J Vilcek
Journal:  Infect Immun       Date:  1981-10       Impact factor: 3.441

6.  An assay procedure for the comparative irritancy testing of esters in the tigliane and daphnane series.

Authors:  F J Evans; R J Schmidt
Journal:  Inflammation       Date:  1979-07       Impact factor: 4.092

7.  The effects of the anti-tumor agent mezerein on the cytotoxic capacity and oxidative metabolism of human blood cells.

Authors:  K Barton; G Randall; A L Sagone
Journal:  Invest New Drugs       Date:  1989-07       Impact factor: 3.850

Review 8.  Structural insights into C1-ligand interactions: Filling the gaps by in silico methods.

Authors:  Sachin Katti; Tatyana I Igumenova
Journal:  Adv Biol Regul       Date:  2021-01-18

9.  Antimicrobial inhibitory activity of aqueous, hydroalcoholic and alcoholic extracts of leaves and stem of Daphne mucronata on growth of oral bacteria.

Authors:  Kolsoom Shirzadi Karamolah; Fatemeh Mousavi; Hassan Mahmoudi
Journal:  GMS Hyg Infect Control       Date:  2017-10-02

10.  Phytochemical Analysis and Biological Activities of the Ethanolic Extract of Daphne sericea Vahl Flowering Aerial Parts Collected in Central Italy.

Authors:  Claudio Frezza; Alessandro Venditti; Daniela De Vita; Fabio Sciubba; Pierpaolo Tomai; Marco Franceschin; Mirella Di Cecco; Giampiero Ciaschetti; Antonella Di Sotto; Annarita Stringaro; Marisa Colone; Alessandra Gentili; Mauro Serafini; Armandodoriano Bianco
Journal:  Biomolecules       Date:  2021-03-03
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