Literature DB >> 11142847

Cytotoxicity of extractives from Taiwania cryptomerioides heartwood.

S T Chang1, D S Wang, C L Wu, S G Shiah, Y H Kuo, C J Chang.   

Abstract

The cytotoxicity of the dominant lignans and sesquiterpenoids from Taiwania (Taiwania cryptomerioides Hayata) was investigated. Three human tumor cells including A-549 lung carcinoma. MCF-7 breast adenocarcinoma and HT-29 colon adenocarcinoma were selected to illustrate the structure-cytotoxicity relationships of Taiwania's dominant compounds. Taiwanin A, taiwanin E and dimethylmatairesinol exhibited significant cytotoxicity against three human tumor cells. Among them, taiwanin A possesses the strongest cytotoxic activity. In addition, the morphology-based evaluation, flow cytometric analysis, and DNA fragmentation assays demonstrated that the tumor cell death induced by taiwanin A was due to apoptosis.

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Year:  2000        PMID： 11142847     DOI： 10.1016/s0031-9422(00)00275-2

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  8 in total

1.  Highly stereoselective synthesis of (Z)- and (E)-chloro-substituted-α-methylene-γ-butyrolactone by possibly controlling cis- and trans-chloropalladation.

Authors:  Yi Dong; Xiaoyong Guo; Yuanyuan Yu; Gang Liu
Journal:  Mol Divers       Date:  2013-01-10       Impact factor: 2.943

2.  Asymmetric total syntheses of megacerotonic acid and shimobashiric acid A.

Authors:  Scott W Krabbe; Jeffrey S Johnson
Journal:  Org Lett       Date:  2015-02-20       Impact factor: 6.005

Review 3.  An Ethnopharmacological, Phytochemical and Pharmacological Review on Lignans from Mexican Bursera spp.

Authors:  Maria Carla Marcotullio; Massimo Curini; Judith X Becerra
Journal:  Molecules       Date:  2018-08-08       Impact factor: 4.411

4.  Taiwanin E Induces Cell Cycle Arrest and Apoptosis in Arecoline/4-NQO-Induced Oral Cancer Cells Through Modulation of the ERK Signaling Pathway.

Authors:  Shih-Hao Wang; Hsi-Chin Wu; Khan Farheen Badrealam; Yueh-Hsiung Kuo; Yun-Peng Chao; Hsi-Hsien Hsu; Da-Tian Bau; Vijaya Padma Viswanadha; Yi-Hui Chen; Pei-Jei Lio; Chung-Jen Chiang; Chih-Yang Huang
Journal:  Front Oncol       Date:  2019-12-17       Impact factor: 6.244

5.  Differential Gene Profiling of the Heartwood Formation Process in Taiwania cryptomerioides Hayata Xylem Tissues.

Authors:  Ting-Feng Yeh; Jui-Hua Chu; Li-Yuan Liu; Shih-Yin Chen
Journal:  Int J Mol Sci       Date:  2020-01-31       Impact factor: 5.923

6.  Cytotoxicity and Apoptosis Induction of 6,7-Dehydroroyleanone from Taiwania cryptomerioides Bark Essential Oil in Hepatocellular Carcinoma Cells.

Authors:  Guan-Rong Chen; Mei-Ling Chang; Shang-Tzen Chang; Yu-Tung Ho; Hui-Ting Chang
Journal:  Pharmaceutics       Date:  2022-02-02       Impact factor: 6.321

7.  Asymmetric total synthesis of four bioactive lignans using donor-acceptor cyclopropanes and bioassay of (-)- and (+)-niranthin against hepatitis B and influenza viruses.

Authors:  Ryotaro Ota; Daichi Karasawa; Mizuki Oshima; Koichi Watashi; Noriko Shimasaki; Yoshinori Nishii
Journal:  RSC Adv       Date:  2022-02-07       Impact factor: 3.361

8.  Persea declinata (Bl.) Kosterm Bark Crude Extract Induces Apoptosis in MCF-7 Cells via G0/G1 Cell Cycle Arrest, Bcl-2/Bax/Bcl-xl Signaling Pathways, and ROS Generation.

Authors:  Putri Narrima; Mohammadjavad Paydar; Chung Yeng Looi; Yi Li Wong; Hairin Taha; Won Fen Wong; Mustafa Ali Mohd; A Hamid A Hadi
Journal:  Evid Based Complement Alternat Med       Date:  2014-04-07       Impact factor: 2.629
  8 in total

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