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Authors: Emanuel Raschi; Elisabetta Poluzzi; Chiara Zuliani; Arno Muller; Herman Goossens; Fabrizio De Ponti
Journal: Br J Clin Pharmacol Date: 2008-11-17 Impact factor: 4.335

3. Adverse drug reactions related to the use of fluoroquinolone antimicrobials: an analysis of spontaneous reports and fluoroquinolone consumption data from three italian regions.

Authors: Roberto Leone; Mauro Venegoni; Domenico Motola; Ugo Moretti; Valentina Piazzetta; Alfredo Cocci; Domenico Resi; Federico Mozzo; Giampaolo Velo; Liliana Burzilleri; Nicola Montanaro; Anita Conforti
Journal: Drug Saf Date: 2003 Impact factor: 5.606

Risk of torsades de pointes with non-cardiac drugs. Prolongation of QT interval is probably a class effect of fluoroquinolones.

1. QTC interval prolongation and polymorphic ventricular tachycardia in association with levofloxacin.

2. Risk of torsades de pointes with non-cardiac drugs. Doctors need to be aware that many drugs can cause qt prolongation.

3. Hay fever drug to become prescription only.

Review 4. Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance.

5. Ethanol enhances the hemodynamic effects of felodipine.

6. Sparfloxacin but not levofloxacin or ofloxacin prolongs cardiac repolarization in rabbit Purkinje fibers.

Review 1. Drug-induced proarrhythmia: risk factors and electrophysiological mechanisms.

Review 2. Exposure to antibacterial agents with QT liability in 14 European countries: trends over an 8-year period.

3. Adverse drug reactions related to the use of fluoroquinolone antimicrobials: an analysis of spontaneous reports and fluoroquinolone consumption data from three italian regions.

Review 4. QT prolongation with antimicrobial agents: understanding the significance.

5. Efficacy and safety of levofloxacin in the context of other contemporary fluoroquinolones: a review.

6. Effects of three fluoroquinolones on QT analysis after standard treatment courses.

7. Mechanism of hERG K+ channel blockade by the fluoroquinolone antibiotic moxifloxacin.