Two new acetylenic derivatives and a new meroditerpenoid from a Taiwanese marine sponge Strongylophora durissima.

Further chemical examination of the sponge Strongylophora durissima yielded two new acetylenic derivatives, durissimols A (1) and B (2), and a new meroditerpenoid, strongylophorine-12 (5), in addition to the known acetylenic compounds, reneirin-2 (3), 18-hydroxyreneirin-2, melyne-C (4), duryne, siphanochalynol, and 24-ethylcholesterol (7). Among them, durissimol B (2) and duryne showed potent cytotoxicity against human gastric tumor (NUGC) cells.