| Literature DB >> 11140739 |
M Raoul1, C Schaeffer, S Léonce, A Pierré, G Atassi, R Hocquemiller, G Lewin.
Abstract
Original cytotoxic bisindole alkaloids with a 1,2,3,4-tetrahydroquinoline bridge were synthesized by reductive amination with various anilines. The most cytotoxic compounds display a high and dose-dependent cell cycle effect with accumulation in the G1 phase. Influence of substitution of the starting aniline on the reaction and on cytotoxicity of produced dimers was pointed out.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11140739 DOI： 10.1016/s0960-894x(00)00600-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823