| Literature DB >> 11140724 |
S W Wright1, D L Hageman, L D McClure, A A Carlo, J L Treadway, A M Mathiowetz, J M Withka, P H Bauer.
Abstract
Anilinoquinazolines currently of interest as inhibitors of tyrosine kinases have been found to be allosteric inhibitors of the enzyme fructose 1,6-bisphosphatase. These represent a new approach to inhibition of F16BPase and serve as leads for further drug design. Enzyme inhibition is achieved by binding at an unidentified allosteric site.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11140724 DOI： 10.1016/s0960-894x(00)00586-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823