Literature DB >> 11139844

The therapeutic potential of iron chelators.

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Abstract

In recent years there has been much interest in the development of iron (Fe) chelators for treatment of a number of clinical conditions in addition to beta-thalassaemia. These include cancer, anthracycline-mediated cardiotoxicity, malaria, AIDS and the severe neurodegenerative disease, Friedreich's ataxia. In this review I will discuss the most recent advances achieved in the potential treatment of these conditions using Fe chelators.

Entities:  

Year:  1999        PMID： 11139844     DOI： 10.1517/13543784.8.12.2141

Source DB:  PubMed          Journal:  Expert Opin Investig Drugs        ISSN： 1354-3784            Impact factor:   6.206


  9 in total

1.  Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents.

Authors:  Don Antoine Lanfranchi; Elena Cesar-Rodo; Benoît Bertrand; Hsin-Hung Huang; Latasha Day; Laure Johann; Mourad Elhabiri; Katja Becker; David L Williams; Elisabeth Davioud-Charvet
Journal:  Org Biomol Chem       Date:  2012-07-10       Impact factor: 3.876

2.  Nanoparticle and iron chelators as a potential novel Alzheimer therapy.

Authors:  Gang Liu; Ping Men; George Perry; Mark A Smith
Journal:  Methods Mol Biol       Date:  2010

3.  Metal chelators coupled with nanoparticles as potential therapeutic agents for Alzheimer's disease.

Authors:  Gang Liu; Ping Men; George Perry; Mark A Smith
Journal:  J Nanoneurosci       Date:  2009-06-01

4.  Interactions of the pyridine-2-carboxaldehyde isonicotinoyl hydrazone class of chelators with iron and DNA: implications for toxicity in the treatment of iron overload disease.

Authors:  Timothy B Chaston; Des R Richardson
Journal:  J Biol Inorg Chem       Date:  2003-02-05       Impact factor: 3.358

5.  An Antioxidant Extract of the Insectivorous Plant Drosera burmannii Vahl. Alleviates Iron-Induced Oxidative Stress and Hepatic Injury in Mice.

Authors:  Nikhil Baban Ghate; Dipankar Chaudhuri; Abhishek Das; Sourav Panja; Nripendranath Mandal
Journal:  PLoS One       Date:  2015-05-26       Impact factor: 3.240

6.  Hepatoprotective Potential of Caesalpinia crista against Iron-Overload-Induced Liver Toxicity in Mice.

Authors:  Rhitajit Sarkar; Bibhabasu Hazra; Nripendranath Mandal
Journal:  Evid Based Complement Alternat Med       Date:  2012-07-17       Impact factor: 2.629

7.  Curcumin Attenuates Iron Accumulation and Oxidative Stress in the Liver and Spleen of Chronic Iron-Overloaded Rats.

Authors:  Farid A Badria; Ahmed S Ibrahim; Adel F Badria; Ahmed A Elmarakby
Journal:  PLoS One       Date:  2015-07-31       Impact factor: 3.240

8.  Investigation of the biological properties of (hetero)aromatic thiosemicarbazones.

Authors:  Maciej Serda; Anna Mrozek-Wilczkiewicz; Josef Jampilek; Matus Pesko; Katarina Kralova; Marcela Vejsova; Robert Musiol; Alicja Ratuszna; Jaroslaw Polanski
Journal:  Molecules       Date:  2012-11-14       Impact factor: 4.411

Review 9.  The Role of the Antioxidant Response in Mitochondrial Dysfunction in Degenerative Diseases: Cross-Talk between Antioxidant Defense, Autophagy, and Apoptosis.

Authors:  Michael L-H Huang; Shannon Chiang; Danuta S Kalinowski; Dong-Hun Bae; Sumit Sahni; Des R Richardson
Journal:  Oxid Med Cell Longev       Date:  2019-04-07       Impact factor: 6.543
  9 in total

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