G Carles1, A Talarmin, C Peneau, M Bertsch. 1. Service de Gynécologie-Obstétrique, Centre Hospitalier Franck Joly, avenue de Gaulle, 97320 Saint-Laurent-du-Maroni, Guyane.
Abstract
OBJECTIVES: Evaluation of the consequences of a dengue fever infection on mother and foetus during pregnancy. PATIENTS AND METHODS: Between February 1, 1992 and December 31, 1999, 172 patients with non malaria hyperthermia were tested for dengue fever infection at the maternity of the Saint-Laurent-du-Maroni hospital in French Guyana. The diagnosis was considered positive when specific IgM was present and/or with virus isolation or viral ARN detection using RT-PCR. Among the 38 cases of mothers infected by dengue fever throughout the three trimesters of pregnancy, it was possible to take 19 fetal blood samples. RESULTS: The major consequences for the mothers were risk of premature delivery in 55% of the cases, one case of severe hemorrhagic complications during a cesarean section, and one case of abruptio placentae. The consequences for the fetus were premature birth in 22% of the cases, 5 in utero fetal deaths, 4 cases of acute fetal distress during labor and 2 cases of mother-to-child transmission. CONCLUSION: In case of dengue fever infection of the mother during pregnancy, there is a serious risk of premature birth and fetal death. In case of infection close to term, there is a risk of hemorrhage for both the mother and the newborn.
OBJECTIVES: Evaluation of the consequences of a dengue fever infection on mother and foetus during pregnancy. PATIENTS AND METHODS: Between February 1, 1992 and December 31, 1999, 172 patients with non malaria hyperthermia were tested for dengue fever infection at the maternity of the Saint-Laurent-du-Maroni hospital in French Guyana. The diagnosis was considered positive when specific IgM was present and/or with virus isolation or viral ARN detection using RT-PCR. Among the 38 cases of mothers infected by dengue fever throughout the three trimesters of pregnancy, it was possible to take 19 fetal blood samples. RESULTS: The major consequences for the mothers were risk of premature delivery in 55% of the cases, one case of severe hemorrhagic complications during a cesarean section, and one case of abruptio placentae. The consequences for the fetus were premature birth in 22% of the cases, 5 in utero fetal deaths, 4 cases of acute fetal distress during labor and 2 cases of mother-to-child transmission. CONCLUSION: In case of dengue fever infection of the mother during pregnancy, there is a serious risk of premature birth and fetal death. In case of infection close to term, there is a risk of hemorrhage for both the mother and the newborn.
Authors: Carlos Machain-Williams; Eric Raga; Carlos M Baak-Baak; Sungmin Kiem; Bradley J Blitvich; Celso Ramos Journal: Biomed Res Int Date: 2018-01-21 Impact factor: 3.411