Literature DB >> 11139132

New structural and chemical insight into the catalytic mechanism of epoxide hydrolases.

R N Armstrong1, C S Cassidy.   

Abstract

New structural and mechanistic data on epoxide hydrolases provide additional insight into the details of how these enzymes function. The data reveal that, in addition to the catalytic triad located in the core domain that carries out the hydrolytic reaction, there are two tyrosine residues, located in the cap domain, which assist in the initial alkylation event.

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Year:  2000        PMID： 11139132     DOI： 10.1081/dmr-100102337

Source DB:  PubMed          Journal:  Drug Metab Rev        ISSN： 0360-2532            Impact factor:   4.518


  9 in total

1.  Removal of distal protein-water hydrogen bonds in a plant epoxide hydrolase increases catalytic turnover but decreases thermostability.

Authors:  Ann Thomaeus; Agata Naworyta; Sherry L Mowbray; Mikael Widersten
Journal:  Protein Sci       Date:  2008-05-30       Impact factor: 6.725

2.  The base-free chemoselective ring opening of epoxides with carboxylic acids using [bmim]Br: a rapid entry into 1,2-diol mono-esters synthesis.

Authors:  Mohammad Navid Soltani Rad; Somayeh Behrouz
Journal:  Mol Divers       Date:  2012-11-07       Impact factor: 2.943

3.  Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif.

Authors:  Christopher D Bahl; Kelli L Hvorecny; Christophe Morisseau; Scott A Gerber; Dean R Madden
Journal:  Biochemistry       Date:  2016-01-22       Impact factor: 3.162

4.  Stereochemical features of the hydrolysis of 9,10-epoxystearic acid catalysed by plant and mammalian epoxide hydrolases.

Authors:  Stephan Summerer; Abdulsamie Hanano; Shigeru Utsumi; Michael Arand; Francis Schuber; Elizabeth Blée
Journal:  Biochem J       Date:  2002-09-01       Impact factor: 3.857

5.  Homology modeling of a novel epoxide hydrolase (EH) from Aspergillus niger SQ-6: structure-activity relationship in expoxides inhibiting EH activity.

Authors:  Quan Luo; Yuan Yao; Wei-Wei Han; Yi-Han Zhou; Ze-Sheng Li
Journal:  J Mol Model       Date:  2009-02-21       Impact factor: 1.810

6.  Determinants of reactivity and selectivity in soluble epoxide hydrolase from quantum mechanics/molecular mechanics modeling.

Authors:  Richard Lonsdale; Simon Hoyle; Daniel T Grey; Lars Ridder; Adrian J Mulholland
Journal:  Biochemistry       Date:  2012-02-10       Impact factor: 3.162

7.  Exploring the origins of selectivity in soluble epoxide hydrolase from Bacillus megaterium.

Authors:  Eila Serrano-Hervás; Marc Garcia-Borràs; Sílvia Osuna
Journal:  Org Biomol Chem       Date:  2017-10-25       Impact factor: 3.876

Review 8.  Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration.

Authors:  Morteza Sarparast; Devon Dattmore; Jamie Alan; Kin Sing Stephen Lee
Journal:  Nutrients       Date:  2020-11-16       Impact factor: 5.717

9.  The crystal structure of mycobacterial epoxide hydrolase A.

Authors:  Eike C Schulz; Sara R Henderson; Boris Illarionov; Thomas Crosskey; Stacey M Southall; Boris Krichel; Charlotte Uetrecht; Markus Fischer; Matthias Wilmanns
Journal:  Sci Rep       Date:  2020-10-06       Impact factor: 4.379
  9 in total

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