| Literature DB >> 11138772 |
P Allavena1, A Sica, A Vecchi, M Locati, S Sozzani, A Mantovani.
Abstract
Localization in tissues and migration to lymphoid organs are essential steps in the immunobiology of dendritic cells (DC). Chemokines play an important role in guiding the traffic of DC. Receptor expression and responsiveness to constitutively made chemokines account for the presence of DC in normal tissues. Inflammatory chemokines and non-chemokine attractants promote recruitment and localization of DC at sites of inflammation and infection. During maturation, DC undergo a profound and orderly rearrangement of their chemokine receptor repertoire. The chemokine receptor switch paradigm provides a conceptual framework for the complex migration of DC in vivo, including their recruitment and positioning in tumor tissues.Entities:
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Year: 2000 PMID： 11138772 DOI： 10.1034/j.1600-065x.2000.17714.x
Source DB: PubMed Journal: Immunol Rev ISSN： 0105-2896 Impact factor: 12.988