Literature DB >> 11137753

Aquaporin subtypes in rat cerebral microvessels.

H Kobayashi1, S Minami, S Itoh, S Shiraishi, H Yokoo, T Yanagita, Y Uezono, M Mohri, A Wada.   

Abstract

We investigated the expression of aquaporin (AQP) subtypes in the rat cerebral microvessels by reverse transcription-polymerase chain reaction, immunoblotting and immunohistochemistry. mRNA for AQP4, but not for AQP1, 2, 3 or 5, was detected in the microvessels. Immunoblot analysis showed that AQP4 protein was detected as a 30 kDa band with higher molecular weight bands. Immunohistochemical staining showed that AQP4 was located on cell surface of the cerebral microvessels. These results suggest that AQP4 in the cerebral microvessels is involved in the regulation of water transport between blood and brain.

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Year:  2001        PMID： 11137753     DOI： 10.1016/s0304-3940(00)01705-5

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  11 in total

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4.  Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet.

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Review 6.  Aquaporin water channels and endothelial cell function.

Authors:  A S Verkman
Journal:  J Anat       Date:  2002-06       Impact factor: 2.610

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Review 9.  [Neuromyelitis optica].

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10.  Dynamic relationship between neurostimulation and N-acetylaspartate metabolism in the human visual cortex: evidence that NAA functions as a molecular water pump during visual stimulation.

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