Literature DB >> 11137150

5-HT(3) receptors and neurotransmitter release in the CNS: a nerve ending story?

J A van Hooft1, H P Vijverberg.   

Abstract

Serotonin (5-HT) 5-HT(3) receptors are ligand-gated ion channels, which are generally thought to be involved in the presynaptic modulation of neurotransmitter release. However, analysis of published data reveals that most of the evidence for the alleged presynaptic role of 5-HT(3) receptors in modulating CNS neurotransmitter release is not compelling. Nevertheless, 5-HT(3) receptors are present in nerve terminals from some brain regions. The increased basic knowledge of the cellular physiology of central 5-HT(3) receptor ligand-gated ion channels provides opportunities for a detailed characterization of the specific presynaptic effects of 5-HT(3) receptors. Such reconsideration is required for the full appreciation of the functional role of 5-HT(3) receptors in the CNS.

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Year:  2000        PMID： 11137150     DOI： 10.1016/s0166-2236(00)01662-3

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  20 in total

1.  Co-expression of the 5-HT3B serotonin receptor subunit alters the biophysics of the 5-HT3 receptor.

Authors:  G Hapfelmeier; C Tredt; R Haseneder; W Zieglgänsberger; B Eisensamer; R Rupprecht; G Rammes
Journal:  Biophys J       Date:  2003-03       Impact factor: 4.033

2.  Serotonin 5-HT(3) receptors in rat CA1 hippocampal interneurons: functional and molecular characterization.

Authors:  Sterling N Sudweeks; Johannes A van Hooft; Jerrel L Yakel
Journal:  J Physiol       Date:  2002-11-01       Impact factor: 5.182

3.  Effects of ethanol on adenosine 5'-triphosphate-gated purinergic and 5-hydroxytryptamine receptors.

Authors:  Daryl L Davies; Liana Asatryan; Sacha T Kuo; John J Woodward; Brian F King; Ronald L Alkana; Cheng Xiao; Jiang Hong Ye; Hui Sun; Li Zhang; Xiang-Qun Hu; Volodya Hayrapetyan; David M Lovinger; Tina K Machu
Journal:  Alcohol Clin Exp Res       Date:  2006-02       Impact factor: 3.455

Review 4.  Modulation of ligand-gated ion channels by antidepressants and antipsychotics.

Authors:  Gerhard Rammes; Rainer Rupprecht
Journal:  Mol Neurobiol       Date:  2007-04       Impact factor: 5.590

Review 5.  Non-synaptic receptors and transporters involved in brain functions and targets of drug treatment.

Authors:  E S Vizi; A Fekete; R Karoly; A Mike
Journal:  Br J Pharmacol       Date:  2010-02-05       Impact factor: 8.739

6.  Agonist- and antagonist-induced up-regulation of surface 5-HT3 A receptors.

Authors:  Russell A Morton; Daniel T Baptista-Hon; Tim G Hales; David M Lovinger
Journal:  Br J Pharmacol       Date:  2015-07-06       Impact factor: 8.739

7.  Attenuation of 1-(m-chlorophenyl)-biguanide induced hippocampus-dependent memory impairment by a standardised extract of Bacopa monniera (BESEB CDRI-08).

Authors:  Koilmani Emmanuvel Rajan; Hemant K Singh; Arunagiri Parkavi; Prisila Dulcy Charles
Journal:  Neurochem Res       Date:  2011-07-07       Impact factor: 3.996

8.  Improvements in hippocampal-dependent learning and decremental attention in 5-HT(3) receptor overexpressing mice.

Authors:  Amber V Harrell; Andrea M Allan
Journal:  Learn Mem       Date:  2003 Sep-Oct       Impact factor: 2.460

9.  Auto-inhibition at a ligand-gated ion channel: a cross-talk between orthosteric and allosteric sites.

Authors:  Xiang-Qun Hu
Journal:  Br J Pharmacol       Date:  2014-11-24       Impact factor: 8.739

10.  Modulation of 5-HT3 receptor desensitization by the light chain of microtubule-associated protein 1B expressed in HEK 293 cells.

Authors:  Hui Sun; Xiang-Qun Hu; Michel B Emerit; Jeffrey C Schoenebeck; Cassin E Kimmel; Robert W Peoples; Angela Miko; Li Zhang
Journal:  J Physiol       Date:  2007-12-06       Impact factor: 5.182
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