| Literature DB >> 11137058 |
C Caldji1, J Diorio, M J Meaney.
Abstract
Naturally occurring variations in maternal care in early postnatal life are associated with the development of individual differences in behavioral and hypothalamic-pituitary-adrenal responses to stress in the rat. These effects appear to be mediated by the influence of maternal licking/grooming on the development of central systems that serve to activate (corticotropin-releasing factor) or inhibit (gamma-aminobutyric acid) the expression of behavioral and endocrine responses to stress through effects on forebrain noradrenergic systems. Importantly, individual differences in maternal care are transmitted from mother to daughter, providing a mechanism for the behavioral transmission of individual differences in stress reactivity across generations.Entities:
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Year: 2000 PMID: 11137058 DOI: 10.1016/s0006-3223(00)01084-2
Source DB: PubMed Journal: Biol Psychiatry ISSN: 0006-3223 Impact factor: 13.382