Literature DB >> 11137058

Variations in maternal care in infancy regulate the development of stress reactivity.

C Caldji1, J Diorio, M J Meaney.   

Abstract

Naturally occurring variations in maternal care in early postnatal life are associated with the development of individual differences in behavioral and hypothalamic-pituitary-adrenal responses to stress in the rat. These effects appear to be mediated by the influence of maternal licking/grooming on the development of central systems that serve to activate (corticotropin-releasing factor) or inhibit (gamma-aminobutyric acid) the expression of behavioral and endocrine responses to stress through effects on forebrain noradrenergic systems. Importantly, individual differences in maternal care are transmitted from mother to daughter, providing a mechanism for the behavioral transmission of individual differences in stress reactivity across generations.

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Year:  2000        PMID: 11137058     DOI: 10.1016/s0006-3223(00)01084-2

Source DB:  PubMed          Journal:  Biol Psychiatry        ISSN: 0006-3223            Impact factor:   13.382


  120 in total

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Review 8.  Maternal separation alters drug intake patterns in adulthood in rats.

Authors:  M C Moffett; A Vicentic; Marie Kozel; Paul Plotsky; D D Francis; M J Kuhar
Journal:  Biochem Pharmacol       Date:  2006-09-08       Impact factor: 5.858

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