Literature DB >> 11136811

High levels of resistance to metronidazole and clarithromycin in Helicobacter pylori strains in children.

N Kalach1, M Bergeret, P H Benhamou, C Dupont, J Raymond.   

Abstract

The aim of the study was to evaluate the prevalence of resistance to amoxicillin, metronidazole, and clarithromycin before treatment of Helicobacter pylori infection in children and to assess the evolution of resistance with time. The study was carried out between 1994 and 1999 with 150 H. pylori-positive children through gastric culture (antimicrobial susceptibility) and histology. All cultured H. pylori strains were sensitive to amoxicillin, 64 (43%) were resistant to metronidazole, 32 (21%) were resistant to clarithromycin, and 14 (9%) were resistant to both metronidazole and clarithromycin. The overall prevalence of resistance to metronidazole and clarithromycin did not change significantly with time. The study highlights the generalized high-level and stable metronidazole and clarithromycin resistance of H. pylori strains from children.

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Year:  2001        PMID： 11136811      PMCID： PMC87742          DOI： 10.1128/JCM.39.1.394-397.2001

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  23 in total

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  13 in total

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5.  Clarithromycin resistance and eradication of Helicobacter pylori in children.

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Authors:  Selim Aydemir; Sedat Boyacioglu; Gurden Gur; Muge Demirbilek; Fusun-Kamber Can; Murat Korkmaz; Ugur Yilmaz
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8.  Efficacy of two triple eradication regimens in children with Helicobacter pylori infection.

Authors:  Jungi Choi; Joo Young Jang; Joon Sung Kim; Hwa Young Park; Yon Ho Choe; Kyung Mo Kim
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Authors:  G Gościniak; B Iwańczak; A Przondo-Mordarska; J Grabińska; F Iwańczak
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10.  Clarithromycin resistance among Helicobacter pylori strains isolated from children: prevalence and study of mechanism of resistance by PCR-restriction fragment length polymorphism analysis.

Authors:  Teresa Alarcón; Alba E Vega; Diego Domingo; Maria Josefa Martínez; Manuel López-Brea
Journal:  J Clin Microbiol       Date:  2003-01       Impact factor: 5.948
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