OBJECTIVE: This study evaluated neurologic functioning in adolescents with schizophrenia with onset of psychosis before age 13. METHOD: The authors administered a structured neurologic examination to 21 adolescents with early-onset schizophrenia and 27 healthy age- and sex-matched comparison subjects. RESULTS: The adolescents with schizophrenia had a high frequency of neurologic abnormalities. Neurologic signs decreased with age in the healthy comparison subjects but not in the subjects with schizophrenia. CONCLUSIONS: The adolescents with schizophrenia had a high burden of neurologic impairment and a pattern of abnormalities similar to that of adults with schizophrenia. The persistence of neurologic signs in the adolescents with schizophrenia, which faded with age in the healthy comparison adolescents, supports earlier evidence of a delay in or failure of normal brain development during adolescence.
OBJECTIVE: This study evaluated neurologic functioning in adolescents with schizophrenia with onset of psychosis before age 13. METHOD: The authors administered a structured neurologic examination to 21 adolescents with early-onset schizophrenia and 27 healthy age- and sex-matched comparison subjects. RESULTS: The adolescents with schizophrenia had a high frequency of neurologic abnormalities. Neurologic signs decreased with age in the healthy comparison subjects but not in the subjects with schizophrenia. CONCLUSIONS: The adolescents with schizophrenia had a high burden of neurologic impairment and a pattern of abnormalities similar to that of adults with schizophrenia. The persistence of neurologic signs in the adolescents with schizophrenia, which faded with age in the healthy comparison adolescents, supports earlier evidence of a delay in or failure of normal brain development during adolescence.
Authors: P M Thompson; C Vidal; J N Giedd; P Gochman; J Blumenthal; R Nicolson; A W Toga; J L Rapoport Journal: Proc Natl Acad Sci U S A Date: 2001-09-25 Impact factor: 11.205
Authors: M Allin; M Rooney; T Griffiths; M Cuddy; J Wyatt; L Rifkin; R Murray Journal: J Neurol Neurosurg Psychiatry Date: 2006-04 Impact factor: 10.154
Authors: Tony W Wilson; Donald C Rojas; Peter D Teale; Olivia O Hernandez; Ryan M Asherin; Martin L Reite Journal: Psychiatry Res Date: 2007-08-28 Impact factor: 3.222
Authors: Rebecca A Berman; Stephen J Gotts; Harrison M McAdams; Dede Greenstein; Francois Lalonde; Liv Clasen; Rebecca E Watsky; Lorie Shora; Anna E Ordonez; Armin Raznahan; Alex Martin; Nitin Gogtay; Judith Rapoport Journal: Brain Date: 2015-10-22 Impact factor: 13.501