OBJECTIVE: There is some evidence of thalamic abnormalities in schizophrenia. This study investigated thalamic volumes in patients experiencing their first episode of psychosis and nonpsychotic comparison subjects. METHOD: Magnetic resonance imaging scans were obtained for 38 patients and 29 comparison subjects. Patients' symptoms were rated by research psychiatrists using the Positive and Negative Syndrome Scale. RESULTS: Thalamic volumes were smaller in patients than in comparison subjects. There were no significant correlations between thalamic volumes and symptom scores. CONCLUSIONS: Thalamic abnormalities are present close to the onset of psychosis.
OBJECTIVE: There is some evidence of thalamic abnormalities in schizophrenia. This study investigated thalamic volumes in patients experiencing their first episode of psychosis and nonpsychotic comparison subjects. METHOD: Magnetic resonance imaging scans were obtained for 38 patients and 29 comparison subjects. Patients' symptoms were rated by research psychiatrists using the Positive and Negative Syndrome Scale. RESULTS: Thalamic volumes were smaller in patients than in comparison subjects. There were no significant correlations between thalamic volumes and symptom scores. CONCLUSIONS:Thalamic abnormalities are present close to the onset of psychosis.
Authors: Laerke Gebser Krohne; Yi Wang; Jesper L Hinrich; Morten Moerup; Raymond C K Chan; Kristoffer H Madsen Journal: Hum Brain Mapp Date: 2019-08-12 Impact factor: 5.038
Authors: Rajendra A Morey; Seniha Inan; Teresa V Mitchell; Diana O Perkins; Jeffrey A Lieberman; Aysenil Belger Journal: Arch Gen Psychiatry Date: 2005-03
Authors: Lei Wang; Daniel Mamah; Michael P Harms; Meghana Karnik; Joseph L Price; Mokhtar H Gado; Paul A Thompson; Deanna M Barch; Michael I Miller; John G Csernansky Journal: Biol Psychiatry Date: 2008-09-23 Impact factor: 13.382
Authors: Denise M Coscia; Katherine L Narr; Delbert G Robinson; Liberty S Hamilton; Serge Sevy; Katherine E Burdick; Handan Gunduz-Bruce; Joanne McCormack; Robert M Bilder; Philip R Szeszko Journal: Hum Brain Mapp Date: 2009-04 Impact factor: 5.038