Literature DB >> 11134348

Viral cyclin-cyclin-dependent kinase 6 complexes initiate nuclear DNA replication.

H Laman1, D Coverley, T Krude, R Laskey, N Jones.   

Abstract

The cyclins encoded by Kaposi sarcoma-associated herpesvirus and herpesvirus saimiri are homologs of human D-type cyclins. However, when complexed to cdk6, they have several activities that distinguish them from D-type cyclin-cdk6 complexes, including resistance to cyclin-dependent kinase inhibitors and an enhanced substrate range. We find that viral cyclins interact with and phosphorylate proteins involved in replication initiation. Using mammalian in vitro replication systems, we show that viral cyclin-cdk6 complexes can directly trigger the initiation of DNA synthesis in isolated late-G(1)-phase nuclei. Viral cyclin-cdk6 complexes share this capacity with cyclin A-cdk2, demonstrating that in addition to functioning as G(1)-phase cyclin-cdk complexes, they function as S-phase cyclin-cdk complexes.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11134348      PMCID： PMC86634          DOI： 10.1128/MCB.21.2.624-635.2001

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  68 in total

1.  Mimosine arrests proliferating human cells before onset of DNA replication in a dose-dependent manner.

Authors:  T Krude
Journal:  Exp Cell Res       Date:  1999-02-25       Impact factor: 3.905

Review 2.  Replication conrol: choreographing replication origins.

Authors:  J F Diffley
Journal:  Curr Biol       Date:  1998-10-22       Impact factor: 10.834

3.  Cdc6 protein causes premature entry into S phase in a mammalian cell-free system.

Authors:  K Stoeber; A D Mills; Y Kubota; T Krude; P Romanowski; K Marheineke; R A Laskey; G H Williams
Journal:  EMBO J       Date:  1998-12-15       Impact factor: 11.598

4.  The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

Authors:  T Durfee; K Becherer; P L Chen; S H Yeh; Y Yang; A E Kilburn; W H Lee; S J Elledge
Journal:  Genes Dev       Date:  1993-04       Impact factor: 11.361

5.  Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.

Authors:  B O Petersen; J Lukas; C S Sørensen; J Bartek; K Helin
Journal:  EMBO J       Date:  1999-01-15       Impact factor: 11.598

6.  Primary structure of the herpesvirus saimiri genome.

Authors:  J C Albrecht; J Nicholas; D Biller; K R Cameron; B Biesinger; C Newman; S Wittmann; M A Craxton; H Coleman; B Fleckenstein
Journal:  J Virol       Date:  1992-08       Impact factor: 5.103

7.  Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex.

Authors:  M Ellis; Y P Chew; L Fallis; S Freddersdorf; C Boshoff; R A Weiss; X Lu; S Mittnacht
Journal:  EMBO J       Date:  1999-02-01       Impact factor: 11.598

8.  Modulation of p27(Kip1) levels by the cyclin encoded by Kaposi's sarcoma-associated herpesvirus.

Authors:  D J Mann; E S Child; C Swanton; H Laman; N Jones
Journal:  EMBO J       Date:  1999-02-01       Impact factor: 11.598

9.  Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

Authors:  M Meyerson; E Harlow
Journal:  Mol Cell Biol       Date:  1994-03       Impact factor: 4.272

10.  A family of human cdc2-related protein kinases.

Authors:  M Meyerson; G H Enders; C L Wu; L K Su; C Gorka; C Nelson; E Harlow; L H Tsai
Journal:  EMBO J       Date:  1992-08       Impact factor: 11.598
View more
  26 in total

1.  CAK-independent activation of CDK6 by a viral cyclin.

Authors:  P Kaldis; P M Ojala; L Tong; T P Mäkelä; M J Solomon
Journal:  Mol Biol Cell       Date:  2001-12       Impact factor: 4.138

2.  Site-specific and temporally controlled initiation of DNA replication in a human cell-free system.

Authors:  Christian Keller; Olivier Hyrien; Rolf Knippers; Torsten Krude
Journal:  Nucleic Acids Res       Date:  2002-05-15       Impact factor: 16.971

3.  RPA is an initiation factor for human chromosomal DNA replication.

Authors:  Dávid Szüts; Lisa Kitching; Christo Christov; Aidan Budd; Sew Peak-Chew; Torsten Krude
Journal:  Nucleic Acids Res       Date:  2003-03-15       Impact factor: 16.971

4.  KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2.

Authors:  Mark Cannon; Ethel Cesarman; Chris Boshoff
Journal:  Blood       Date:  2005-09-08       Impact factor: 22.113

5.  Functional requirement of noncoding Y RNAs for human chromosomal DNA replication.

Authors:  Christo P Christov; Timothy J Gardiner; Dávid Szüts; Torsten Krude
Journal:  Mol Cell Biol       Date:  2006-09       Impact factor: 4.272

6.  Kaposi's sarcoma-associated herpesvirus K-cyclin interacts with Cdk9 and stimulates Cdk9-mediated phosphorylation of p53 tumor suppressor.

Authors:  Pei-Ching Chang; Mengtao Li
Journal:  J Virol       Date:  2007-10-17       Impact factor: 5.103

7.  Identification of BV/ODV-C42, an Autographa californica nucleopolyhedrovirus orf101-encoded structural protein detected in infected-cell complexes with ODV-EC27 and p78/83.

Authors:  S C Braunagel; P A Guidry; G Rosas-Acosta; L Engelking; M D Summers
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

Review 8.  Cell cycle regulation during viral infection.

Authors:  Sumedha Bagga; Michael J Bouchard
Journal:  Methods Mol Biol       Date:  2014

9.  Viral cyclin promotes KSHV-induced cellular transformation and tumorigenesis by overriding contact inhibition.

Authors:  Tiffany Jones; Suzane Ramos da Silva; Roble Bedolla; Fengchun Ye; Fuchun Zhou; Shou-Jiang Gao
Journal:  Cell Cycle       Date:  2014-01-13       Impact factor: 4.534

Review 10.  Targeted therapy for Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus.

Authors:  Dirk P Dittmer; Susan E Krown
Journal:  Curr Opin Oncol       Date:  2007-09       Impact factor: 3.645
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.