| Literature DB >> 11133384 |
K S MacDonald1, J E Embree, N J Nagelkerke, J Castillo, S Ramhadin, S Njenga, J Oyug, J Ndinya-Achola, B H Barber, J J Bwayo, F A Plummer.
Abstract
Certain HLAs may, in part, account for differences in human immunodeficiency virus type 1 (HIV-1) susceptibility by presenting conserved immunogenic epitopes for T cell recognition. The HLA supertype A2/6802 is associated with decreased susceptibility to HIV-1 among sex workers. The alleles in this supertype present the same HIV-1 peptide epitopes for T cell recognition in some cases. This study sought to determine whether the HLA A2/6802 supertype influenced HIV-1 transmission in a prospective cohort of HIV-1-infected mothers and children in Kenya. Decreased perinatal HIV-1 infection risk was strongly associated with possession of a functional cluster of related HLA alleles, called the A2/6802 supertype (odds ratio, 0.12; 95% confidence interval, 0.03-0.54; P=.006). This effect was independent of the protective effect of maternal-child HLA discordance. These data provide further evidence that HLA supertypes are associated with differential susceptibility to HIV-1 transmission.Entities:
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Year: 2000 PMID： 11133384 DOI： 10.1086/318092
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226