| Literature DB >> 11133101 |
N Zhang1, B Wu, D Powell, A Wissner, M B Floyd, E D Kovacs, L Toral-Barza, C Kohler.
Abstract
A series of 3-cyano-4-(phenoxyanilino)cyanoquinolines has been prepared as MEK (MAP kinase kinase) inhibitors. The best activity is seen with alkoxy groups at both the 6- and 7-positions. The lead compounds show low nanomolar IC50's against MAP kinase kinase, and have potent inhibitory activity in tumor cells.Entities:
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Year: 2000 PMID： 11133101 DOI： 10.1016/s0960-894x(00)00580-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823