| Literature DB >> 11133094 |
B Walker1, M F Brown, J F Lynas, S L Martin, A McDowell, B Badet, A J Hill.
Abstract
A series of electrophilic glutamine analogues based on 6-diazo-5-oxo-norleucine has been prepared, using novel synthetic routes, and evaluated as inhibitors of Escherichia coli glucosamine synthetase. The gamma-dimethylsulphonium salt analogue of glutamine was found to be one of the most potent inactivators of this enzyme yet reported, with an apparent second order rate constant (k2/Ki) of 3.5 x 10(5) M(-1) min(-1).Entities:
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Year: 2000 PMID： 11133094 DOI： 10.1016/s0960-894x(00)00565-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823