Literature DB >> 11133092

A novel pyridazinone derivative as a nonprostanoid PGI2 agonist.

K Tsubaki1, K Taniguchi, S Tabuchi, O Okitsu, K Hattori, J Seki, K Sakane, H Tanaka.   

Abstract

A novel optically pure pyridazinone derivative was synthesized and identified as a nonprostanoid PGI2 agonist. It inhibited ADP-induced aggregation of human platelets with an IC50 value of 0.081 microM and has high oral bioavailability (56%) with a long half-life (4.3 h) in rats.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 11133092     DOI： 10.1016/s0960-894x(00)00571-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

Review 1.  Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn.

Authors:  Batoule H Majed; Raouf A Khalil
Journal:  Pharmacol Rev       Date:  2012-06-07       Impact factor: 25.468

2.  Synthesis of novel IP agonists via N-aminoethyl cyclic amines prepared by decarboxylative ring-opening reactions.

Authors:  Yasuhiro Morita; Takeshi Ishigaki; Kuniaki Kawamura; Ryoji Hayashi; Masafumi Isogaya; Mika Kitsukawa; Mitsuko Miyamoto; Masashi Uchida; Katsuhiko Iseki
Journal:  Molecules       Date:  2012-01-31       Impact factor: 4.411
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.