Literature DB >> 11133043

Heritability of chromosomal radiosensitivity in breast cancer patients: a pilot study with the lymphocyte micronucleus assay.

W Burrill1, J B Barber, S A Roberts, B Bulman, D Scott.   

Abstract

Of breast cancer patients, 30% are sensitive in a lymphocyte assay of radiation-induced chromosome damage (micronucleus induction) compared with 10% of healthy controls. Twenty-two first-degree relatives of 11 sensitive patients had an average micronucleus yield significantly higher than that of 68 controls. This suggests that radiosensitivity in this assay may be an inherited characteristic associated with predisposition to breast cancer.

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Year:  2000        PMID： 11133043     DOI： 10.1080/09553000050201109

Source DB:  PubMed          Journal:  Int J Radiat Biol        ISSN： 0955-3002            Impact factor:   2.694


  10 in total

Review 1.  Molecular contribution of BRCA1 and BRCA2 to genome instability in breast cancer patients: review of radiosensitivity assays.

Authors:  Fatemeh Sadeghi; Marzieh Asgari; Mojdeh Matloubi; Maral Ranjbar; Nahid Karkhaneh Yousefi; Tahereh Azari; Majid Zaki-Dizaji
Journal:  Biol Proced Online       Date:  2020-10-01       Impact factor: 3.244

2.  G2-phase chromosomal radiosensitivity of primary fibroblasts from hereditary retinoblastoma family members and some apparently normal controls.

Authors:  Paul F Wilson; Hatsumi Nagasawa; Markus M Fitzek; John B Little; Joel S Bedford
Journal:  Radiat Res       Date:  2010-01       Impact factor: 2.841

3.  Breast cancer risk following Hodgkin lymphoma radiotherapy in relation to menstrual and reproductive factors.

Authors:  R Cooke; M E Jones; D Cunningham; S J Falk; D Gilson; B W Hancock; S J Harris; A Horwich; P J Hoskin; T Illidge; D C Linch; T A Lister; H H Lucraft; J A Radford; A M Stevens; I Syndikus; M V Williams; A J Swerdlow
Journal:  Br J Cancer       Date:  2013-05-07       Impact factor: 7.640

Review 4.  Role of micronucleus test in predicting breast cancer susceptibility: a systematic review and meta-analysis.

Authors:  F Cardinale; P Bruzzi; C Bolognesi
Journal:  Br J Cancer       Date:  2011-12-20       Impact factor: 7.640

5.  Search for inherited susceptibility to radiation-associated meningioma by genomewide SNP linkage disequilibrium mapping.

Authors:  F J Hosking; D Feldman; R Bruchim; B Olver; A Lloyd; J Vijayakrishnan; P Flint-Richter; P Broderick; R S Houlston; S Sadetzki
Journal:  Br J Cancer       Date:  2011-03-01       Impact factor: 7.640

6.  Sensitivity to radiation-induced chromosome damage may be a marker of genetic predisposition in young head and neck cancer patients.

Authors:  R Papworth; N Slevin; S A Roberts; D Scott
Journal:  Br J Cancer       Date:  2001-03-23       Impact factor: 7.640

7.  Clinical application of micronucleus test: a case-control study on the prediction of breast cancer risk/susceptibility.

Authors:  Claudia Bolognesi; Paolo Bruzzi; Viviana Gismondi; Samantha Volpi; Valeria Viassolo; Simona Pedemonte; Liliana Varesco
Journal:  PLoS One       Date:  2014-11-21       Impact factor: 3.240

8.  Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition.

Authors:  A Baeyens; H Thierens; K Claes; B Poppe; L Messiaen; L De Ridder; A Vral
Journal:  Br J Cancer       Date:  2002-12-02       Impact factor: 7.640

9.  Radiosensitivity in breast cancer assessed by the Comet and micronucleus assays.

Authors:  C S Djuzenova; B Mühl; M Fehn; U Oppitz; B Müller; M Flentje
Journal:  Br J Cancer       Date:  2006-04-24       Impact factor: 7.640

Review 10.  Clinical and Functional Assays of Radiosensitivity and Radiation-Induced Second Cancer.

Authors:  Mohammad Habash; Luis C Bohorquez; Elizabeth Kyriakou; Tomas Kron; Olga A Martin; Benjamin J Blyth
Journal:  Cancers (Basel)       Date:  2017-10-27       Impact factor: 6.639
  10 in total

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