Literature DB >> 11132946

6-(hydroxyalkyl)penicillanates as probes for mechanisms of beta-lactamases.

D Golemi1, L Maveyraud, A Ishiwata, S Tranier, K Miyashita, T Nagase, I Massova, L Mourey, J P Samama, S Mobashery.   

Abstract

6-(Hydroxyalkyl)penicillanates have proven helpful as probes for the mechanisms of beta-lactamases, enzymes of resistance for beta-lactam antibiotics. The present report summarizes the concepts on design, syntheses and use of these molecules in mechanistic studies of beta-lactamases.

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Year:  2000        PMID： 11132946     DOI： 10.7164/antibiotics.53.1022

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  9 in total

1.  Hydrolytic mechanism of OXA-58 enzyme, a carbapenem-hydrolyzing class D β-lactamase from Acinetobacter baumannii.

Authors:  Vidhu Verma; Sebastian A Testero; Kaveh Amini; William Wei; Jerome Liu; Naresh Balachandran; Tharseekan Monoharan; Siobhan Stynes; Lakshmi P Kotra; Dasantila Golemi-Kotra
Journal:  J Biol Chem       Date:  2011-08-31       Impact factor: 5.157

2.  Modifications of the C6-substituent of penicillin sulfones with the goal of improving inhibitor recognition and efficacy.

Authors:  Micheal Nottingham; Christopher R Bethel; Sundar Ram Reddy Pagadala; Emily Harry; Abishai Pinto; Zachary A Lemons; Sarah M Drawz; Focco van den Akker; Paul R Carey; Robert A Bonomo; John D Buynak
Journal:  Bioorg Med Chem Lett       Date:  2010-11-05       Impact factor: 2.823

Review 3.  Class D β-lactamases: a reappraisal after five decades.

Authors:  David A Leonard; Robert A Bonomo; Rachel A Powers
Journal:  Acc Chem Res       Date:  2013-07-31       Impact factor: 22.384

4.  Regiospecific syntheses of 6alpha-(1R-Hydroxyoctyl)penicillanic acid and 6beta-(1R-hydroxyoctyl)penicillanic acid as mechanistic probes of class D beta-lactamases.

Authors:  Sebastian A Testero; Peter I O'Daniel; Qicun Shi; Mijoon Lee; Dusan Hesek; Akihiro Ishiwata; Bruce C Noll; Shahriar Mobashery
Journal:  Org Lett       Date:  2009-06-18       Impact factor: 6.005

5.  Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics.

Authors:  Jason W Labonte; Fumitaka Kudo; Michael F Freeman; Mary L Raber; Craig A Townsend
Journal:  Medchemcomm       Date:  2012-01-01       Impact factor: 3.597

Review 6.  Three decades of the class A beta-lactamase acyl-enzyme.

Authors:  Jed F Fisher; Shahriar Mobashery
Journal:  Curr Protein Pept Sci       Date:  2009-10       Impact factor: 3.272

Review 7.  Three decades of beta-lactamase inhibitors.

Authors:  Sarah M Drawz; Robert A Bonomo
Journal:  Clin Microbiol Rev       Date:  2010-01       Impact factor: 26.132

8.  Active-Site Plasticity Is Essential to Carbapenem Hydrolysis by OXA-58 Class D β-Lactamase of Acinetobacter baumannii.

Authors:  Shivendra Pratap; Madhusudhanarao Katiki; Preet Gill; Pravindra Kumar; Dasantila Golemi-Kotra
Journal:  Antimicrob Agents Chemother       Date:  2015-10-12       Impact factor: 5.191

9.  Detecting a quasi-stable imine species on the reaction pathway of SHV-1 β-lactamase and 6β-(hydroxymethyl)penicillanic acid sulfone.

Authors:  Tao Che; Elizabeth A Rodkey; Christopher R Bethel; Sivaprakash Shanmugam; Zhe Ding; Marianne Pusztai-Carey; Michael Nottingham; Weirui Chai; John D Buynak; Robert A Bonomo; Focco van den Akker; Paul R Carey
Journal:  Biochemistry       Date:  2015-01-08       Impact factor: 3.162
  9 in total

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