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Literature DB >> 11131521

Establishment of left-right asymmetry.

Abstract

The vertebrate body plan has bilateral symmetry and left-right asymmetries that are highly conserved. The molecular pathways for left-right development are beginning to be elucidated. Several distinct mechanisms to initiate the vertebrate left-right axis have been proposed. These mechanisms appear to converge on highly conserved expression patterns of genes in the transforming growth factor-beta (TGFbeta) family of cell-cell signaling factors, nodal and lefty-2, and subsequently the expression of the transcription regulator Pitx2, in left lateral plate mesoderm. It is possible that downstream signaling pathways diverge in distinct classes of vertebrates.

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Year: 2001 PMID： 11131521 DOI： 10.1016/s0074-7696(01)03011-x

Source DB: PubMed Journal: Int Rev Cytol ISSN： 0074-7696

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Cited

11 in total

1. Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness.

Authors: Daniel H Geschwind; Bruce L Miller; Charles DeCarli; Dorit Carmelli
Journal: Proc Natl Acad Sci U S A Date: 2002-02-26 Impact factor: 11.205

2. Left and right contributions to the Xenopus heart: implications for asymmetric morphogenesis.

Authors: Joseph P Gormley; Nanette M Nascone-Yoder
Journal: Dev Genes Evol Date: 2003-05-23 Impact factor: 0.900

3. The ATP-sensitive K(+)-channel (K(ATP)) controls early left-right patterning in Xenopus and chick embryos.

Authors: Sherry Aw; Joseph C Koster; Wade Pearson; Colin G Nichols; Nian-Qing Shi; Katia Carneiro; Michael Levin
Journal: Dev Biol Date: 2010-07-17 Impact factor: 3.582

4. Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates.

Authors: Dany S Adams; Kenneth R Robinson; Takahiro Fukumoto; Shipeng Yuan; R Craig Albertson; Pamela Yelick; Lindsay Kuo; Megan McSweeney; Michael Levin
Journal: Development Date: 2006-03-22 Impact factor: 6.868

Review 5. Gap junctional communication in morphogenesis.

Authors: Michael Levin
Journal: Prog Biophys Mol Biol Date: 2007-03-16 Impact factor: 3.667

6. H,K-ATPase protein localization and Kir4.1 function reveal concordance of three axes during early determination of left-right asymmetry.

Authors: Sherry Aw; Dany S Adams; Dayong Qiu; Michael Levin
Journal: Mech Dev Date: 2007-11-04 Impact factor: 1.882

Establishment of left-right asymmetry.

1. Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness.

2. Left and right contributions to the Xenopus heart: implications for asymmetric morphogenesis.

3. The ATP-sensitive K(+)-channel (K(ATP)) controls early left-right patterning in Xenopus and chick embryos.

4. Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates.

Review 5. Gap junctional communication in morphogenesis.

6. H,K-ATPase protein localization and Kir4.1 function reveal concordance of three axes during early determination of left-right asymmetry.

7. Differential roles for 3-OSTs in the regulation of cilia length and motility.

8. Polarity proteins are required for left-right axis orientation and twin-twin instruction.

9. Notch signaling regulates left-right asymmetry determination by inducing Nodal expression.

10. Nt mutation causing laterality defects associated with deletion of rotatin.