Literature DB >> 11130206

Microdialysis sampling of the isothiazolone, PD-161374, and its thiol and disulfide metabolites.

M Ye1, D T Rossi, C E Lunte.   

Abstract

A method based on microdialysis sampling combined with high-performance liquid chromatography (HPLC) has been developed for monitoring the anti-HIV agent PD-161374 (isothiazolone) and its thiol and disulfide metabolites in blood. It was demonstrated that unlike blood withdraw and extraction, microdialysis sampling can preserve the distribution among the isothiazolone and its metabolites in blood. The use of a narrow-bore HPLC system, combined with the relatively high probe extraction efficiency (approximately 50%) from the flexible probe design in this work, allows the direct and quantitative determination of the drug and its major metabolites at submicromolar level.

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Year:  2000        PMID： 11130206      PMCID： PMC2519828          DOI： 10.1016/s0731-7085(00)00418-0

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  8 in total

Review 1.  Application of microdialysis in pharmacokinetic studies.

Authors:  W F Elmquist; R J Sawchuk
Journal:  Pharm Res       Date:  1997-03       Impact factor: 4.200

2.  Inhibitors of HIV nucleocapsid protein zinc fingers as candidates for the treatment of AIDS.

Authors:  W G Rice; J G Supko; L Malspeis; R W Buckheit; D Clanton; M Bu; L Graham; C A Schaeffer; J A Turpin; J Domagala; R Gogliotti; J P Bader; S M Halliday; L Coren; R C Sowder; L O Arthur; L E Henderson
Journal:  Science       Date:  1995-11-17       Impact factor: 47.728

3.  Examination of microdialysis sampling in a well-characterized hydrodynamic system.

Authors:  J A Stenken; E M Topp; M Z Southard; C E Lunte
Journal:  Anal Chem       Date:  1993-09-01       Impact factor: 6.986

4.  Simultaneous determination of the elimination profiles of the individual enantiomers of racemic isoproterenol using capillary electrophoresis and microdialysis sampling.

Authors:  M E Hadwiger; S Park; S R Torchia; C E Lunte
Journal:  J Pharm Biomed Anal       Date:  1997-02       Impact factor: 3.935

5.  2,2'-Dithiobisbenzamides and 2-benzisothiazolones, two new classes of antiretroviral agents: SAR and mechanistic considerations.

Authors:  J M Domagala; R Gogliotti; J P Sanchez; M A Stier; K Musa; Y Song; J Loo; M Reily; P Tummino; P Harvey; D Hupe; L Sharmeen; D Mack; J Scholten; J Saunders; T McQuade
Journal:  Drug Des Discov       Date:  1997-05

6.  A new class of anti-HIV-1 agents targeted toward the nucleocapsid protein NCp7: the 2,2'-dithiobisbenzamides.

Authors:  J M Domagala; J P Bader; R D Gogliotti; J P Sanchez; M A Stier; Y Song; J V Prasad; P J Tummino; J Scholten; P Harvey; T Holler; S Gracheck; D Hupe; W G Rice; R Schultz
Journal:  Bioorg Med Chem       Date:  1997-03       Impact factor: 3.641

7.  Intravenous microdialysis sampling in awake, freely-moving rats.

Authors:  M Telting-Diaz; D O Scott; C E Lunte
Journal:  Anal Chem       Date:  1992-04-01       Impact factor: 6.986

8.  The in vitro ejection of zinc from human immunodeficiency virus (HIV) type 1 nucleocapsid protein by disulfide benzamides with cellular anti-HIV activity.

Authors:  P J Tummino; J D Scholten; P J Harvey; T P Holler; L Maloney; R Gogliotti; J Domagala; D Hupe
Journal:  Proc Natl Acad Sci U S A       Date:  1996-02-06       Impact factor: 11.205
  8 in total

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