Literature DB >> 11129955

Study on the relationship between calcium-induced calcium release from mitochondria and PTP opening.

X Huang1, D Zhai, Y Huang.   

Abstract

The permeability transition pore (PTP) is central for mitochondria function. PTP either open in low-conductance state to carry out mCICR (Ca2+-induced Ca2+ release from mitochondria) and play roles in cell phsyiological activities or open in high-conductance conformation to release harmful substances and play important roles in cell pathological responses and apoptosis. The results of study on the relationship between mCICR and PTP opening show Ca2+ concentrations but not the Ca2+ delivery mode determined the occurrence of mCICR or PTP opening. Ca2+-induced PTP opening began with and depended on mCICR. mCICR was a prerequisite for H2O2 and As2O3-induced PTP opening. The results indicated that the PTP opening was determined by Ca2+ stimulation intensity but not mode. PTP could switch from low- to high-conductance conformation and the PTP open by high-conductance began with low-conductance state. mCICR is necessary for Ca2+-dependent PTP opening. Our data suggested also that it would be possible to control cellular responses first by modulating mCICR, then by regulating PTP opening.

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Year:  2000        PMID： 11129955     DOI： 10.1023/a:1007138818124

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  21 in total

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  7 in total

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4.  Resveratrol-induced mitochondrial dysfunction and apoptosis are associated with Ca2+ and mCICR-mediated MPT activation in HepG2 cells.

Authors:  Xiaodong Ma; Xuemei Tian; Xingxu Huang; Fang Yan; Dongfang Qiao
Journal:  Mol Cell Biochem       Date:  2007-03-30       Impact factor: 3.396

5.  Regulation of mitochondrial permeability transition pore by PINK1.

Authors:  Clement A Gautier; Emilie Giaime; Erica Caballero; Lucía Núñez; Zhiyin Song; David Chan; Carlos Villalobos; Jie Shen
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6.  Studying mitochondrial Ca(2+) uptake - a revisit.

Authors:  Claire Jean-Quartier; Alexander I Bondarenko; Muhammad Rizwan Alam; Michael Trenker; Markus Waldeck-Weiermair; Roland Malli; Wolfgang F Graier
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7.  Inhibition of metabotropic glutamate receptor 5 induces cellular stress through pertussis toxin-sensitive Gi-proteins in murine BV-2 microglia cells.

Authors:  Boonrat Chantong; Denise V Kratschmar; Adam Lister; Alex Odermatt
Journal:  J Neuroinflammation       Date:  2014-11-19       Impact factor: 8.322
  7 in total

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