Literature DB >> 111289

Naloxone antagonizes theophylline-induced potentiation of morphine inhibition of a nociceptive reaction in rats.

G Paalzow.   

Abstract

In the rat, theophylline has been shown to potentiate the effect of morphine on the threshold for vocalisation after withdrawal of stimulation. This response to painful stimulation is considered to be integrated at the level of the thalamus-hypothalamus-rhinencephalon. Naloxone antagonized the effect of the combined treatment with morphine and theophylline, suggesting pharmacological specificity for morphine. Moreover, the theophylline-induced enhancement of this pharmacological response to morphine was attenuated after pimozide pretreatment, indicating an underlying dopaminergic mechanism.

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Year:  1979        PMID： 111289     DOI： 10.1007/bf00431953

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  27 in total

1.  Effect of morphine on a depolarising dopamine response.

Authors:  P R Myers; D R Livengood; W Shain
Journal:  Nature       Date:  1975-09-18       Impact factor: 49.962

2.  Further studies on the behavioural and biochemical interaction between caffeine and L-DOPA.

Authors:  U Strömberg; B Waldeck
Journal:  J Neural Transm       Date:  1973       Impact factor: 3.575

3.  Theophylline increased sensitivity to nociceptive stimulation and regional turnover of rat brain 5-HT, noradrenaline and dopamine.

Authors:  G Paalzow; L Paalzow
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1974-03

4.  Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor".

Authors:  J W Kebabian; G L Petzold; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1972-08       Impact factor: 11.205

5.  Evidence for dopamine receptor stimulation by apomorphine.

Authors:  N E Andén; A Rubenson; K Fuxe; T Hökfelt
Journal:  J Pharm Pharmacol       Date:  1967-09       Impact factor: 3.765

6.  Compulsive gnawing in rats after implantation of drugs into the ventral thalamus. A contribution to the mechanism of morphine action.

Authors:  F Bergmann; M Chaimovitz; V Pasternak; A Ramu
Journal:  Br J Pharmacol       Date:  1974-06       Impact factor: 8.739

7.  Decrease in morphine's analgesic action and increase in its cataleptic action by 6-hydroxydopamine injected bilaterally into caudate and putamen areas; partial restoration by L-DOPA plus decarboxylase inhibition.

Authors:  K Nakamura; R Kuntzman; A Maggio; A H Conney
Journal:  Neuropharmacology       Date:  1973-12       Impact factor: 5.250

8.  Morphine catalepsy in the rat: relation to striatal dopamine metabolism.

Authors:  K Kuschinsky; O Hornykiewicz
Journal:  Eur J Pharmacol       Date:  1972-07       Impact factor: 4.432

9.  Action of caffeine and theophyllamine on supersensitive dopamine receptors: considerable enhancement of receptor response to treatment with DOPA and dopamine receptor agonists.

Authors:  K Fuxe; U Ungerstedt
Journal:  Med Biol       Date:  1974-02

10.  Monoaminergic mechanisms of stimulation-produced analgesia.

Authors:  H Akil; J C Liebeskind
Journal:  Brain Res       Date:  1975-08-29       Impact factor: 3.252
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