| Literature DB >> 11128639 |
N Murakami1, E Iwata, S Tamura, S Akiyama, M Kobayashi.
Abstract
Three new oligoacylated sucroses designated atractysucroses-I, -II, and -III were obtained from Atractylodis Lanceae Rhizoma as multidrug resistance (MDR) modulating substances against human carcinoma cell lines and their chemical structures were characterized as a mixture of acyl groups. Atractysucrose-I modulates MDR in KB-C2 cells as strongly as verapamil. This is the first example of an MDR-modulator classified as a carbohydrate.Entities:
Mesh：
Year: 2000 PMID： 11128639 DOI： 10.1016/s0960-894x(00)00536-9
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823